Evidence map›Paper›PMID 35630580›Full record

ArticleMolecules (Basel, Switzerland)2022

Integrated Deadenylase Genetic Association Network and Transcriptome Analysis in Thoracic Carcinomas.

Athanasios Kyritsis, Eirini Papanastasi, Ioanna Kokkori, Panagiotis Maragozidis, Demetra S M Chatzileontiadou, Paschalina Pallaki, Maria Labrou, Sotirios G Zarogiannis, George P Chrousos, Dimitrios Vlachakis and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Athanasios KyritsisDepartment of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 415 00 Larissa, Greece.
Eirini PapanastasiDepartment of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 415 00 Larissa, Greece.
Ioanna KokkoriDepartment of Respiratory Medicine, Faculty of Medicine, University of Thessaly, Biopolis, 411 10 Larissa, Greece.
Panagiotis MaragozidisDepartment of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 415 00 Larissa, Greece.ORCID 0000-0002-2414-9681
Demetra S M ChatzileontiadouDepartment of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 415 00 Larissa, Greece.
Paschalina PallakiDepartment of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 415 00 Larissa, Greece.
Maria LabrouDepartment of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 415 00 Larissa, Greece.
Sotirios G ZarogiannisDepartment of Respiratory Medicine, Faculty of Medicine, University of Thessaly, Biopolis, 411 10 Larissa, Greece.
George P ChrousosUniversity Research Institute of Maternal and Child Health and Precision Medicine, 'Aghia Sophia' Children's Hospital, National and Kapodistrian University of Athens, 115 27 Athens, Greece.ORCID 0000-0002-3098-5264
Dimitrios VlachakisUniversity Research Institute of Maternal and Child Health and Precision Medicine, 'Aghia Sophia' Children's Hospital, National and Kapodistrian University of Athens, 115 27 Athens, Greece.ORCID 0000-0003-1823-6102
Konstantinos I GourgoulianisDepartment of Respiratory Medicine, Faculty of Medicine, University of Thessaly, Biopolis, 411 10 Larissa, Greece.
Nikolaos A A BalatsosDepartment of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 415 00 Larissa, Greece.ORCID 0000-0002-1146-1174
University of Thessaly · GRAgricultural University of Athens · GRNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The poly(A) tail at the 3' end of mRNAs determines their stability, translational efficiency, and fate. The shortening of the poly(A) tail, and its efficient removal, triggers the degradation of mRNAs, thus, regulating gene expression. The process is catalyzed by a family of enzymes, known as deadenylases. As the dysregulation of gene expression is a hallmark of cancer, understanding the role of deadenylases has gained additional interest. Herein, the genetic association network shows that CNOT6 and CNOT7 are the most prevalent and most interconnected nodes in the equilibrated diagram. Subsequent silencing and transcriptomic analysis identifies transcripts possibly regulated by specific deadenylases. Furthermore, several gene ontologies are enriched by common deregulated genes. Given the potential concerted action and overlapping functions of deadenylases, we examined the effect of silencing a deadenylase on the remaining ones. Our results suggest that specific deadenylases target unique subsets of mRNAs, whilst at the same time, multiple deadenylases may affect the same mRNAs with overlapping functions.

Indexed as

CarcinomaGene Expression ProfilingGene OntologyHumansRNA, MessengerRNA, Messengerassociation networkdeadenylaseslung cancermRNA degradationtranscriptomics

Identifiers

PMID35630580
PMCPMC9145511
OpenAlexW4280613120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.