Evidence map›Paper›PMID 35630566›Full record

ArticleMolecules (Basel, Switzerland)2022

Screening of Carbonic Anhydrase, Acetylcholinesterase, Butyrylcholinesterase, and α-Glycosidase Enzyme Inhibition Effects and Antioxidant Activity of Coumestrol.

Lokman Durmaz, Adem Erturk, Mehmet Akyüz, Leyla Polat Kose, Eda Mehtap Uc, Zeynebe Bingol, Ruya Saglamtas, Saleh Alwasel, İlhami Gulcin

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 80 citations in OpenAlex.

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  5. Synthesis and structure-activity relationship studies of 1,2,4-triazole-benzoxazepine hybrids as α-glucosidase inhibitors: molecular docking and biological evaluation.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
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  9. Antioxidants: a comprehensive review.Archives of toxicology · 2025
    Review
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  11. Therapeutic potential ofFrontiers in chemistry · 2025
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  12. Review
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  19. Potential antioxidant, anticholinergic, antidiabetic and antiglaucoma activities and molecular docking of spiraeoside as a secondary metabolite of onion (Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Lokman DurmazDepartment of Medical Services and Technology, Cayirli Vocational School, Erzincan Binali Yildirim University, Erzincan 24500, Turkey.
Adem ErturkDepartment of Chemistry, Faculty of Science, Ataturk University, Erzurum 25240, Turkey.
Mehmet AkyüzDepartment of Chemistry, Faculty of Science and Arts, Kilis 7 Aralık University, Kilis 79000, Turkey.
Leyla Polat KoseDepartment of Pharmacy Services, Vocational School, Beykent University, Istanbul 34500, Turkey.
Eda Mehtap UcDepartment of Chemistry, Faculty of Science, Ataturk University, Erzurum 25240, Turkey.ORCID 0000-0002-9259-5704
Zeynebe BingolDepartment of Chemistry, Faculty of Science, Ataturk University, Erzurum 25240, Turkey.
Ruya SaglamtasDepartment of Medical Services and Technology, Vocational School of Health Services, Agri Ibrahim Cecen University, Agri 04100, Turkey.ORCID 0000-0002-4400-2302
Saleh AlwaselDepartment of Zoology, College of Science, King Saud University, Riyadh 11362, Saudi Arabia.
İlhami GulcinDepartment of Chemistry, Faculty of Science, Ataturk University, Erzurum 25240, Turkey.ORCID 0000-0001-5993-1668
Atatürk University · TRAğrı İbrahim Çeçen University · TRBeykent University · TRErzincan Binali Yıldırım University · TRKilis 7 Aralık University · TRKing Saud University · SATokat Gaziosmanpaşa Üniversitesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coumestrol (3,9-dihydroxy-6-benzofuran [3,2-c] chromenone) as a phytoestrogen and polyphenolic compound is a member of the Coumestans family and is quite common in plants. In this study, antiglaucoma, antidiabetic, anticholinergic, and antioxidant effects of Coumestrol were evaluated and compared with standards. To determine the antioxidant activity of coumestrol, several methods-namely N,N-dimethyl-p-phenylenediamine dihydrochloride radical (DMPD

Indexed as

AntioxidantsCarbonic AnhydrasesAcetylcholinesterasealpha-TocopherolButylated HydroxyanisoleButylated HydroxytolueneButyrylcholinesteraseCoumestrolFree Radical ScavengersGlycoside HydrolasesAcetylcholinesterasealpha-TocopherolAntioxidantsButylated HydroxyanisoleButylated HydroxytolueneButyrylcholinesteraseCarbonic AnhydrasesCoumestrolFree Radical ScavengersGlycoside Hydrolasesacetylcholinesteraseantioxidant activitybutyrylcholinesterasecarbonic anhydrasecoumestrolphenolic compoundα-glycosidase

Identifiers

PMID35630566
PMCPMC9143817
OpenAlexW4280624361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.