Facile Synthesis of Tricyclic 1,2,4-Oxadiazolines-Fused Tetrahydro-Isoquinolines from Oxime Chlorides with 3,4-Dihydroisoquinoline Imines.

Kaikai Wang, Yanli Li, Wei Zhang, Rongxiang Chen, Xueji Ma, Mingyue Wang, Nan Zhou

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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1 citing paper in PubMed.

Substrate-Controlled Diversity-Oriented Synthesis of Novel Polycyclic Frameworks via [4 + 2] and [3 + 2] Annulations of Ninhydrin-Derived MBH Adducts with 3,4-Dihydroisoquinolines.Molecules (Basel, Switzerland) · 2023
Article

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5 · Who and what money

Authors and funding

7 authors.

Kaikai WangSchool of Pharmacy, Xinxiang University, Xinxiang 453000, China.

Yanli LiMedical College, Xinxiang University, Xinxiang 453000, China.

Wei ZhangSchool of Pharmacy, Xinxiang University, Xinxiang 453000, China.

Rongxiang ChenSchool of Pharmacy, Xinxiang University, Xinxiang 453000, China.

Xueji MaSchool of Pharmacy, Xinxiang University, Xinxiang 453000, China.

Mingyue WangSchool of Pharmacy, Xinxiang University, Xinxiang 453000, China.

Nan ZhouSchool of Pharmacy, Xinxiang University, Xinxiang 453000, China.

Funding

National Natural Science Foundation of China 21702176National Natural Science Foundation of China 21801214Natural Science Foundation of Henan Province 202300410016Program for Youth Backbone Teacher Training in University of Henan Province 2021GGJS163

6 · The paper itself

Abstract

A mild and efficient strategy for the synthesis of tricyclic 1,2,4-oxadiazolines-fused tetrahydro-isoquinolines derivatives via [3 + 2] cycloaddition reaction is reported. The reactions provided the functionalized tricyclic 1,2,4-oxadiazolines in high yields (up to 96%). This protocol is simple and easy to handle. Moreover, a gram-scale experiment further highlights the synthetic utility. The chemical structure of the product was determined by X-ray single-crystal structure analysis. A possible mechanism for this transformation is proposed to explain the reaction process.

Indexed as

IminesTetrahydroisoquinolinesChloridesIsoquinolinesOximesChloridesG 1616IminesIsoquinolinesOximesTetrahydroisoquinolines1,2,4-oxadiazolinescyclic iminescycloadditionoxime chlorides

Identifiers

PMID35630538

DOI10.3390/molecules27103064

PMCPMC9145198

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