Evidence map›Paper›PMID 35630368›Full record

ReviewMicroorganisms2022

Gram-Negative Bacterial Envelope Homeostasis under Oxidative and Nitrosative Stress.

Thibault Chautrand, Djouhar Souak, Sylvie Chevalier, Cécile Duclairoir-Poc

Abstract readReview
In one paragraph

Review in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
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  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Flow cytometry study ofFrontiers in microbiology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
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  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Thibault ChautrandResearch Unit Bacterial Communication and Anti-infectious Strategies (UR CBSA), Rouen Normandy University, Normandy University, 55 rue Saint-Germain, 27000 Evreux, France.
Djouhar SouakResearch Unit Bacterial Communication and Anti-infectious Strategies (UR CBSA), Rouen Normandy University, Normandy University, 55 rue Saint-Germain, 27000 Evreux, France.
Sylvie ChevalierResearch Unit Bacterial Communication and Anti-infectious Strategies (UR CBSA), Rouen Normandy University, Normandy University, 55 rue Saint-Germain, 27000 Evreux, France.ORCID 0000-0001-6489-438X
Cécile Duclairoir-PocResearch Unit Bacterial Communication and Anti-infectious Strategies (UR CBSA), Rouen Normandy University, Normandy University, 55 rue Saint-Germain, 27000 Evreux, France.ORCID 0000-0001-8386-8769

Funding

Conseil régional de Haute-Normandie CosSeSa P106 N°002082Rédion Normandie/European Regional Development Fund RIN BEE N° 18E017461/18P02897
6 · The paper itself

Abstract

Bacteria are frequently exposed to endogenous and exogenous reactive oxygen and nitrogen species which can damage various biomolecules such as DNA, lipids, and proteins. High concentrations of these molecules can induce oxidative and nitrosative stresses in the cell. Reactive oxygen and nitrogen species are notably used as a tool by prokaryotes and eukaryotes to eradicate concurrent species or to protect themselves against pathogens. The main example is mammalian macrophages that liberate high quantities of reactive species to kill internalized bacterial pathogens. As a result, resistance to these stresses is determinant for the survival of bacteria, both in the environment and in a host. The first bacterial component in contact with exogenous molecules is the envelope. In Gram-negative bacteria, this envelope is composed of two membranes and a layer of peptidoglycan lodged between them. Several mechanisms protecting against oxidative and nitrosative stresses are present in the envelope, highlighting the importance for the cell to deal with reactive species in this compartment. This review aims to provide a comprehensive view of the challenges posed by oxidative and nitrosative stresses to the Gram-negative bacterial envelope and the mechanisms put in place in this compartment to prevent and repair the damages they can cause.

Indexed as

bacterial envelopeGram-negative bacterianitrosative stressoxidative stressRNSROS

Identifiers

PMID35630368
PMCPMC9144841

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.