Stop-Flow Lithography for the Continuous Production of Degradable Hydrogel Achiral Crescent Microswimmers.

Junfeng Xiong, Xiaoxia Song, Yuhang Cai, Jiahe Liu, Yangyuan Li, Yaqiang Ji, Liang Guo, U Kei Cheang

Abstract read

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Article in Micromachines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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3 · Its place in the literature

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1 citing paper in PubMed.

Magnetically-actuated hydrogel-based achiral planar microswimmers for SERS detection: In situ coprecipitation for continuous loading of iron oxide nanoparticles.Frontiers in bioengineering and biotechnology · 2023
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8 authors.

Junfeng XiongSchool of Mechatronics Engineering, Harbin Institute of Technology, Harbin 150001, China.ORCID 0000-0001-5289-1480

Xiaoxia SongDepartment of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen 518055, China.ORCID 0000-0001-6269-8422

Yuhang CaiDepartment of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen 518055, China.

Jiahe LiuDepartment of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen 518055, China.ORCID 0000-0003-4473-0331

Yangyuan LiDepartment of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen 518055, China.

Yaqiang JiSchool of Mechatronics Engineering, Harbin Institute of Technology, Harbin 150001, China.

Liang GuoDepartment of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen 518055, China.

U Kei CheangDepartment of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen 518055, China.

Funding

Junfeng Xiong pdjh2021c0048Liang Guo 2019A1515010745Liang Guo 20200925155828001Liang Guo KQTD20170810110250357U Kei Cheang 20181119590CU Kei Cheang 2021ZDZX2037U Kei Cheang 51850410516U Kei Cheang ZDSYS20200811143601004

6 · The paper itself

Abstract

The small size of robotic microswimmers makes them suitable for performing biomedical tasks in tiny, enclosed spaces. Considering the effects of potentially long-term retention of microswimmers in biological tissues and the environment, the degradability of microswimmers has become one of the pressing issues in this field. While degradable hydrogel was successfully used to prepare microswimmers in previous reports, most hydrogel microswimmers could only be fabricated using two-photon polymerization (TPP) due to their 3D structures, resulting in costly robotic microswimmers solution. This limits the potential of hydrogel microswimmers to be used in applications where a large number of microswimmers are needed. Here, we proposed a new type of preparation method for degradable hydrogel achiral crescent microswimmers using a custom-built stop-flow lithography (SFL) setup. The degradability of the hydrogel crescent microswimmers was quantitatively analyzed, and the degradation rate in sodium hydroxide solution (NaOH) of different concentrations was investigated. Cytotoxicity assays showed the hydrogel crescent microswimmers had good biocompatibility. The hydrogel crescent microswimmers were magnetically actuated using a 3D Helmholtz coil system and were able to obtain a swimming efficiency on par with previously reported microswimmers. The results herein demonstrated the potential for the degradable hydrogel achiral microswimmers to become a candidate for microscale applications.

Indexed as

crescentdegradable hydrogel microswimmersmagnetic actuationstop-flow lithography

Identifiers

PMID35630266

DOI10.3390/mi13050798

PMCPMC9144168

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.