Evidence map›Paper›PMID 35630197›Full record

ReviewMicromachines2022

Microfluidic Platforms for the Isolation and Detection of Exosomes: A Brief Review.

Duraichelvan Raju, Srinivas Bathini, Simona Badilescu, Anirban Ghosh, Muthukumaran Packirisamy

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Micromachines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Anti-Inflammatory and Angiogenic Effects of Stem Cell Secretome.International journal of molecular sciences · 2026
    Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Bioinspired exosome-SiOTheranostics · 2025
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Duraichelvan RajuMicro-Nano-Bio Integration Center, Optical Bio-Microsystems Laboratory, Department of Mechanical Industrial and Aerospace Engineering, Concordia University, Montreal, QC H3G 1M8, Canada.
Srinivas BathiniMicro-Nano-Bio Integration Center, Optical Bio-Microsystems Laboratory, Department of Mechanical Industrial and Aerospace Engineering, Concordia University, Montreal, QC H3G 1M8, Canada.
Simona BadilescuMicro-Nano-Bio Integration Center, Optical Bio-Microsystems Laboratory, Department of Mechanical Industrial and Aerospace Engineering, Concordia University, Montreal, QC H3G 1M8, Canada.
Anirban GhoshMicro-Nano-Bio Integration Center, Optical Bio-Microsystems Laboratory, Department of Mechanical Industrial and Aerospace Engineering, Concordia University, Montreal, QC H3G 1M8, Canada.
Muthukumaran PackirisamyMicro-Nano-Bio Integration Center, Optical Bio-Microsystems Laboratory, Department of Mechanical Industrial and Aerospace Engineering, Concordia University, Montreal, QC H3G 1M8, Canada.ORCID 0000-0002-1769-6986
Concordia University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are a group of communication organelles enclosed by a phospholipid bilayer, secreted by all types of cells. The size of these vesicles ranges from 30 to 1000 nm, and they contain a myriad of compounds such as RNA, DNA, proteins, and lipids from their origin cells, offering a good source of biomarkers. Exosomes (30 to 100 nm) are a subset of EVs, and their importance in future medicine is beyond any doubt. However, the lack of efficient isolation and detection techniques hinders their practical applications as biomarkers. Versatile and cutting-edge platforms are required to detect and isolate exosomes selectively for further clinical analysis. This review paper focuses on lab-on-chip devices for capturing, detecting, and isolating extracellular vesicles. The first part of the paper discusses the main characteristics of different cell-derived vesicles, EV functions, and their clinical applications. In the second part, various microfluidic platforms suitable for the isolation and detection of exosomes are described, and their performance in terms of yield, sensitivity, and time of analysis is discussed.

Indexed as

detectionexosomesisolationlab-on a chipmicrofluidics devices

Identifiers

PMID35630197
PMCPMC9147043
OpenAlexW4225259139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.