Evidence map›Paper›PMID 35629973›Full record

ArticleMetabolites2022

Increased Ammonium Toxicity in Response to Exogenous Glutamine in Metastatic Breast Cancer Cells.

Violet A Kiesel, Madeline P Sheeley, Shawn S Donkin, Michael K Wendt, Stephen D Hursting, Dorothy Teegarden

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Violet A KieselDepartment of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0003-4059-9110
Madeline P SheeleyDepartment of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-5102-0533
Shawn S DonkinDepartment of Animal Science, Purdue University, West Lafayette, IN 47907, USA.
Michael K WendtDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-3665-7413
Stephen D HurstingDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Dorothy TeegardenDepartment of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-7045-3748
Purdue University West Lafayette · USUniversity of North Carolina at Chapel Hill · US

Funding

Higher Dietary Carbohydrates Detrimentally Impact Obesity-Associated Breast Cancer ChemoresistanceR35CA197627 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HURSTING, STEPHEN D · 2015 to 2021
$6.0M
Indiana Clinical and Translational Science Institute (UL1)UL1TR000006 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2012 to 2013
$5.6M
Obesity, Metabolism and Breast Cancer MetastasisR01CA232589 · NCI · PURDUE UNIVERSITY · PI HURSTING, STEPHEN D, TEEGARDEN, DOROTHY · 2019 to 2023
$2.6M
Impact of hypoxia on lipid metabolism in obesity-driven breast cancer progressionR01CA271597 · NCI · PURDUE UNIVERSITY · PI Stephen D Hursting, Dorothy Teegarden · 2023 to 2026
$2.5M
Overcoming metastatic resistance to ErbB-targeted therapiesR01CA207751 · NCI · PURDUE UNIVERSITY · PI WENDT, MICHAEL KEITH · 2017 to 2021
$1.7M
The influence of alcohol on the metastatic dormancy of breast cancerR21AA026675 · NIAAA · PURDUE UNIVERSITY · PI VAN RIJN, RICHARD M., WENDT, MICHAEL KEITH · 2018 to 2019
$280k
NCATS NIH HHS UL1 TR000006NCI NIH HHS R01 CA207751NCI NIH HHS R01 CA232589NCI NIH HHS R01 CA271597NCI NIH HHS R35 CA197627NIAAA NIH HHS R21 AA026675NIH HHS R01CA232589, R35CA197627, R01CA207751, R21AA026675
6 · The paper itself

Abstract

Several cancers, including breast cancers, show dependence on glutamine metabolism. The purpose of the present study was to determine the mechanistic basis and impact of differential glutamine metabolism in nonmetastatic and metastatic murine mammary cancer cells. Universally labeled

Indexed as

ammonium toxicitybreast cancerglutamine metabolismmetabolic reprogrammingmetastasis

Identifiers

PMID35629973
PMCPMC9145280
OpenAlexW4282923975

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.