Evidence map›Paper›PMID 35629872›Full record

ArticleMetabolites2022

A Metabolomic Severity Score for Airflow Obstruction and Emphysema.

Suneeta Godbole, Wassim W Labaki, Katherine A Pratte, Andrew Hill, Matthew Moll, Annette T Hastie, Stephen P Peters, Andrew Gregory, Victor E Ortega, Dawn DeMeo and 9 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01969344 active not recruitingnot on this map

Subpopulations and Intermediate Outcome Measures in COPD Study

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2010 to 2031Enrolled2,981ConditionsCOPD, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Omic Risk Scores are Associated with COPD-related Traits Across Three Cohorts.medRxiv : the preprint server for health sciences · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Limitations of Clustering with PCA and Correlated Noise.Journal of statistical computation and simulation · 2024
    Article
  8. Proteomics and Metabolomics in Biomedicine.International journal of molecular sciences · 2023
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 1 country.

Suneeta GodboleDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-7358-2078
Wassim W LabakiDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Katherine A PratteDivision of Medicine, National Jewish Health, Denver, CO 80206, USA.
Andrew HillDivision of Medicine, National Jewish Health, Denver, CO 80206, USA.ORCID 0000-0001-5468-6616
Matthew MollChanning Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Annette T HastieSection on Pulmonary, Critical Care, Allergy & Immunology, Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, USA.
Stephen P PetersSection on Pulmonary, Critical Care, Allergy & Immunology, Internal Medicine, Atrium Health Wake Forest Baptist, Winston Salem, NC 20157, USA.
Andrew GregoryChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0001-8260-6193
Victor E OrtegaDivision of Respiratory Medicine, Department of Internal Medicine, Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.
Dawn DeMeoChanning Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Michael H ChoChanning Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Surya P BhattDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
J Michael WellsUAB Lung Health Center, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Igor BarjaktarevicDivision of Pulmonary and Critical Care, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-8096-0858
Kathleen A StringerDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-0238-7774
Alejandro ComellasDivision of Pulmonary and Critical Care, University of Iowa, Iowa City, IA 52242, USA.
Wanda O'NealMarsico Lung Institute, University of North Carolina, Chapel Hill, NC 27599, USA.
Katerina KechrisDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-3725-5459
Russell P BowlerDivision of Medicine, National Jewish Health, Denver, CO 80206, USA.
Brigham and Women's Hospital · USNational Jewish Health · USColorado School of Public Health · USUniversity of Alabama at Birmingham · USUniversity of Michigan · USAtrium Health Wake Forest Baptist · USLung Institute · USMayo Clinic · USUniversity of California, Los Angeles · USUniversity of Iowa · USWake Forest University · US

Funding

Biomarker of Lung Disease in African AmericansR01HL137995 · NHLBI · NATIONAL JEWISH HEALTH · PI BOWLER, RUSSELL PAUL, KECHRIS-MAYS, KATHERINA · 2018 to 2021
$3.4M
Multi-omic networks associated with COPD progression in TOPMed CohortsR01HL152735 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BANAEI-KASHANI, FARNOUSH, BOWLER, RUSSELL PAUL · 2020 to 2023
$3.1M
Integrative genomic, transcriptomic and proteomic studies of pulmonary function and COPDR01HL153248 · NHLBI · UNIVERSITY OF VIRGINIA · PI CHO, MICHAEL H., MANICHAIKUL, ANI WANG · 2021 to 2024
$2.8M
Matrikines and COPD-PHR01HL148215 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WELLS, JAMES MICHAEL · 2019 to 2023
$2.4M
Leveraging Serum Metabolomics to Understand Clinical Phenotypes in COPDK23HL151751 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LABAKI, WASSIM W · 2020 to 2024
$875k
NHLBI NIH HHS K23 HL151751NHLBI NIH HHS R01 HL148215NHLBI NIH HHS R01 HL152735NHLBI NIH HHS R01 HL153248
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is a disease with marked metabolic disturbance. Previous studies have shown the association between single metabolites and lung function for COPD, but whether a combination of metabolites could predict phenotype is unknown. We developed metabolomic severity scores using plasma metabolomics from the Metabolon platform from two US cohorts of ever-smokers: the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) (

Indexed as

adaptive LASSOCOPDlung densitymetabolomics

Identifiers

PMID35629872
PMCPMC9143560
OpenAlexW4224304302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.