Evidence map›Paper›PMID 35629820›Full record

ArticleMembranes2022

Understanding the Dynamics of the Transient and Permanent Opening Events of the Mitochondrial Permeability Transition Pore with a Novel Stochastic Model.

Keertana Yalamanchili, Nasrin Afzal, Liron Boyman, Carmen A Mannella, W Jonathan Lederer, M Saleet Jafri

Open access · goldAbstract read
In one paragraph

Article in Membranes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Keertana YalamanchiliSchool of Systems Biology, George Mason University, Fairfax, VA 22030, USA.
Nasrin AfzalSchool of Systems Biology, George Mason University, Fairfax, VA 22030, USA.
Liron BoymanCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Carmen A MannellaCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
W Jonathan LedererCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
M Saleet JafriThomas Jefferson High School for Science and Technology, Alexandria, VA 22312, USA.ORCID 0000-0003-3174-1007
University of Maryland, Baltimore · USGeorge Mason University · US

Funding

Multiscale spatiotemporal modeling of cardiac mitochondriaU01HL116321 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI JAFRI, MOHSIN SALEET, LEDERER, WILLIAM JONATHAN · 2014 to 2018
$3.5M
NHLBI NIH HHS U01 HL116321
6 · The paper itself

Abstract

The mitochondrial permeability transition pore (mPTP) is a non-selective pore in the inner mitochondrial membrane (IMM) which causes depolarization when it opens under conditions of oxidative stress and high concentrations of Ca

Indexed as

computational modeldepolarizationheartmitochondriaMonte Carlo methodmPTPreactive oxygen species (ROS)TMRM

Identifiers

PMID35629820
PMCPMC9146742
OpenAlexW4225249756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.