ArticleMaterials (Basel, Switzerland)2022
Human Gingival Fibroblast Adhesion and Proliferation on Hydroxyapatite-Coated Zirconia Abutment Surfaces.
Article in Materials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- The Biocompatibility and Cellular Response of Geristore in Comparison With Different Glass Ionomer Materials on Human Gingival Fibroblast Cells: A Comparative Study on Deep Marginal Elevation.International journal of biomaterials · 2026Article
- An overview of types of antibacterial coatings and methods for creating them on orthodontic wires.Journal of materials science. Materials in medicine · 2025Review
- Evaluation of Viability and Adhesion of Human Gingival Fibroblast and the Adhesion of Oral Microflora on Thermally Aged Zirconia and BioHPP Abutment Surfaces: An In Vitro Study.International journal of dentistry · 2025Article
- Titanium surfaces with biomimetic topography and copper incorporation to modulate behaviors of stem cells and oral bacteria.Frontiers in bioengineering and biotechnology · 2023Article
- First-Principles Computational Study of the Modification Mechanism of Graphene/Graphene Oxide on Hydroxyapatite.Materials (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Applying antibacterial coatings to dental implant materials seems reasonable but can have negative influences on desired cell adhesion and healing. In this study, zirconia abutment specimens interacting with gingival tissue were used. The aim was to compare the influence of machined or coated zirconia surfaces on the adhesion and proliferation of human gingival fibroblasts (HGF-1). Surface modifications were performed using atmospheric plasma coating with hydroxyapatite, zinc, and copper. Zirconia specimens were divided into four groups: hydroxyapatite, hydroxyapatite with zinc oxide (ZnO), hydroxyapatite with copper (Cu), and an untreated machined surface. After the characterization of the surface conditions, the morphology of adhered HGF-1 was determined by fluorescence staining and subjected to statistical evaluation. The visual analysis of cell morphology by SEM showed flat, polygonal, and largely adherent fibroblast cells in the untreated group, while round to partially flat cells were recorded in the groups with hydroxyapatite, hydroxyapatite + ZnO, and hydroxyapatite + Cu. The cell membranes in the hydroxyapatite + ZnO and hydroxyapatite + Cu groups appeared porous. The results show that HGF-1 adhere and proliferate well on machined zirconia, while plasma coating with hydroxyapatite or hydroxyapatite mixtures does not lead to increased adhesion or proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.