ArticleLife (Basel, Switzerland)2022
The Bootstrap Model of Prebiotic Networks of Proteins and Nucleic Acids.
Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 2 citations in OpenAlex.
- Origins of Life: The Protein Folding Problem all over again?Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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3 authors at 1 institution in 1 country.
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Abstract
It is not known how life arose from prebiotic physical chemistry. How did fruitful cell-like associations emerge from the two polymer types-informational (nucleic acids, xNAs = DNA or RNA) and functional (proteins)? Our model shows how functional networks could bootstrap from random sequence-independent initial states. For proteins, we adopt the foldamer hypothesis: through persistent nonequilibrium prebiotic syntheses, short random peptides fold and catalyze the elongation of others. The xNAs enter through random binding to the peptides, and all chains can mutate. Chains grow inside colloids that split when they're large, coupling faster growth speeds to bigger populations. Random and useless at first, these folding and binding events grow protein-xNA networks that resemble today's protein-protein networks.
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