ReviewLife (Basel, Switzerland)2022
Tendon and Ligament Genetics: How Do They Contribute to Disease and Injury? A Narrative Review.
Review in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Role ofGenes · 2026Pooled it
- Associations ofAging · 2024Pooled it
- Investigating the Association of Genetic Markers, Previously Identified by Genome-Wide Association Studies, With ACL Rupture in Multiple Cohorts.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Shoulder and genetics: what orthopedic surgeons need to know.JSES reviews, reports, and techniques · 2026Review
- Edema and Structural Remodeling in Equine Suspensory Ligament Injury: A Severity Gradient Associated with Microvascular Dysfunction.Animals : an open access journal from MDPI · 2026Article
- Special Issue "Ligament/Tendon and Cartilage Tissue Engineering and Reconstruction".International journal of molecular sciences · 2026Article
- An overview in tendon's physiology, pathomorphology, and treatment options.Cell and tissue research · 2026Review
- Article
- Current Concepts in Pathogenesis and Conservative Management of Supraspinous Tendinopathies Using Shockwave Therapy-A Narrative Review of the Literature.Biomedicines · 2025Review
- [Histopathological diagnostics for assessment questions of tendo-, ligamento-, and meniscus pathologies].Pathologie (Heidelberg, Germany) · 2025Review
- Review
- The impact of nuchal ligament ossification resection on cervical stability after modified laminoplasty: a long-term follow-up study.BMC musculoskeletal disorders · 2025Article
- Comparing Repaired Subscapularis Tendon Integrity Using Ultrasound in Onlay Versus Inlay Reverse Shoulder Arthroplasty.Journal of clinical medicine · 2025Article
- Therapeutic Potential of Quercetin as an Antioxidant for Bone-Muscle-Tendon Regeneration and Aging.Aging and disease · 2024Review
- The Association of Variants within Types V and XI Collagen Genes with Knee Joint Laxity Measurements.Genes · 2022Article
- Functional biomaterials for tendon/ligament repair and regeneration.Regenerative biomaterials · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A significant proportion of patients requiring musculoskeletal management present with tendon and ligament pathology. Our understanding of the intrinsic and extrinsic mechanisms that lead to such disabilities is increasing. However, the complexity underpinning these interactive multifactorial elements is still not fully characterised. Evidence highlighting the genetic components, either reducing or increasing susceptibility to injury, is increasing. This review examines the present understanding of the role genetic variations contribute to tendon and ligament injury risk. It examines the different elements of tendon and ligament structure and considers our knowledge of genetic influence on form, function, ability to withstand load, and undertake repair or regeneration. The role of epigenetic factors in modifying gene expression in these structures is also explored. It considers the challenges to interpreting present knowledge, the requirements, and likely pathways for future research, and whether such information has reached the point of clinical utility.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.