ReviewLife (Basel, Switzerland)2022
Spleen: Reparative Regeneration and Influence on Liver.
Review in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Evaluation of different probiotic administration methods on productive performance, visceral organs, intestinal bacteria, and morphology in broiler chickens.Tropical animal health and production · 2026Article
- Does the spleen regenerate in rabbits after partial splenectomy?Open veterinary journal · 2026Article
- Validation of Baveno VII criteria for recompensation in patients with decompensated cirrhosis treated by laparoscopic splenectomy and azygoportal disconnection.Journal of gastroenterology · 2026Article
- The Impact of Heterotopic Spleen Regeneration on Tumor Growth.FASEB bioAdvances · 2026Article
- Predictive factors for post-embolization infarction and long-term splenic remodeling in patients undergoing splenic artery aneurysm embolization.Frontiers in surgery · 2026Article
- Splenectomy reduces shear stress and inflammation in liver endothelial cells during regeneration after partial hepatectomy in mice.Scientific reports · 2025Article
- Review
- Causal relationship analysis of MRI measurements of major human internal organs and liver disease.European journal of medical research · 2025Article
- Cellular effects of splenectomy on liver regeneration after 70% resection.Frontiers in cell and developmental biology · 2025Article
- The independent prognostic value of perioperative hepatic venous pressure gradient measurements in patients with portal hypertension who underwent laparoscopic splenectomy plus esophagogastric devascularization.BMC gastroenterology · 2024Article
- A large gastric splenosis mimicking gastrointestinal stromal tumor: A case report and literature review.Experimental and therapeutic medicine · 2024Article
- Splenectomy ameliorates liver cirrhosis by restoring the gut microbiota balance.Cellular and molecular life sciences : CMLS · 2024Article
- The role of macrophages in liver fibrosis: composition, heterogeneity, and therapeutic strategies.Frontiers in immunology · 2024Review
- Spleen regeneration after subcutaneous heterotopic autotransplantation in a mouse model.Biological research · 2023Article
- The spleen as a possible source of serine protease inhibitors and migrating monocytes required for liver regeneration after 70% resection in mice.Frontiers in cell and developmental biology · 2023Article
- An Eye on Kupffer Cells: Development, Phenotype and the Macrophage Niche.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
This review considers experimental findings on splenic repair, obtained in two types of small animal (mouse, rat, and rabbit) models: splenic resections and autologous transplantations of splenic tissue. Resection experiments indicate that the spleen is able to regenerate, though not necessarily to the initial volume. The recovery lasts one month and preserves the architecture, albeit with an increase in the relative volume of lymphoid follicles. The renovated tissues, however, exhibit skewed functional profiles; notably, the decreased production of antibodies and the low cytotoxic activity of T cells, consistent with the decline of T-dependent zones and prolonged reduction in T cell numbers. Species-specific differences are evident as well, with the post-repair organ mass deficiency most pronounced in rabbit models. Autotransplantations of splenic material are of particular clinical interest, as the procedure can possibly mitigate the development of post-splenectomy syndrome. Under these conditions, regeneration lasts 1-2 months, depending on the species. The transplants effectively destroy senescent erythrocytes, assist in microbial clearance, and produce antibodies, thus averting sepsis and bacterial pneumonia. Meanwhile, cellular sources of splenic recovery in such models remain obscure, as well as the time required for T and B cell number reconstitution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.