ArticleJournal of clinical medicine2022
Association between Body Mass Index and Renal Outcomes Modified by Chronic Kidney Disease and Anemia: The Obesity Paradox for Renal Outcomes.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Lifestyle and Metabolic Health, Low-Grade to Clinically Elevated Albuminuria, and Cardiovascular-Renal Diseases.JACC. Asia · 2026Article
- Prevalence and factors associated with malnutrition among patients with pre-dialysis chronic kidney disease stages 3-5.Narra J · 2026Article
- Article
- Different types of anemia in patients with chronic kidney disease.Pakistan journal of medical sciences · 2025Article
- Physical activity, cardiovascular disease, and mortality across obesity levels.The EPMA journal · 2025Article
- Determinants of Anemia Among Patients with Chronic Kidney Disease: A Systematic Review of Empirical Evidence.Journal of multidisciplinary healthcare · 2025Review
- Zinc deficiency predicts new-onset diabetic kidney disease in type 2 diabetes: a retrospective cohort study.Frontiers in nutrition · 2025Article
- Approaches to patients with obesity and CKD: focus on nutrition and surgery.Clinical kidney journal · 2024Article
- Kidney Damage in Pediatric Obesity: Insights from an Emerging Perspective.Journal of clinical medicine · 2024Article
- Approximation of Glomerular Filtration Rate after 1 Year Using Annual Medical Examination Data.Journal of clinical medicine · 2024Article
- Lipid parameters, adipose tissue distribution and prognosis prediction in chronic kidney Disease patients.Lipids in health and disease · 2024Article
- Prevalence, Characteristics, and Outcomes of People With A High Body Mass Index Across the Kidney Disease Spectrum: A Population-Based Cohort Study.Canadian journal of kidney health and disease · 2024Article
- Non-insulin-based insulin resistance indices for predicting all-cause mortality and renal outcomes in patients with stage 1-4 chronic kidney disease: another paradox.Frontiers in nutrition · 2023Article
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
Obesity-related nephropathy is associated with renal function progression. However, some studies have associated a high body mass index (BMI) with improved renal outcomes—this is referred to as the obesity paradox for renal outcomes, especially in relation to advanced chronic kidney disease (CKD). Central obesity can explain the obesity paradox in all-cause mortality. However, whether obesity or central obesity is associated with renal outcomes (renal replacement therapy or a 50% decline in the estimated glomerular filtration rate) in patients with advanced CKD remains unclear. Our study included 3605 Asian patients with CKD stages 1−5 divided into six groups according to their BMI (between 15 and 35 kg/m2). Through linear regression, BMI was positively associated with hemoglobin and albumin at CKD stages 4 and 5. In the competing risk Cox regression model, a high BMI (27.5−35 kg/m2) was associated with renal outcomes at CKD stages 1−3, but not stages 4 and 5. A high BMI was associated with renal outcomes in patients with hemoglobin ≥11 g/dL, but not <11 g/dL. A high waist-to-hip ratio was not associated with renal outcomes. We conclude that the CKD stage and anemia may explain the obesity paradox in renal outcomes in patients with CKD.
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