Evidence map›Paper›PMID 35628630›Full record

ArticleInternational journal of molecular sciences2022

Lifestyles Shape the Cytochrome P450 Repertoire of the Bacterial Phylum

Siphesihle Msweli, Andiswa Chonco, Lihle Msweli, Puleng Rosinah Syed, Rajshekhar Karpoormath, Wanping Chen, Dominik Gront, Bridget Valeria Zinhle Nkosi, David R Nelson, Khajamohiddin Syed

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Siphesihle MsweliDepartment of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand, KwaDlangezwa 3886, South Africa.ORCID 0000-0002-9516-0028
Andiswa ChoncoDepartment of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand, KwaDlangezwa 3886, South Africa.
Lihle MsweliDepartment of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand, KwaDlangezwa 3886, South Africa.
Puleng Rosinah SyedDepartment of Pharmaceutical Chemistry, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.
Rajshekhar KarpoormathDepartment of Pharmaceutical Chemistry, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.ORCID 0000-0002-1247-5754
Wanping ChenDepartment of Molecular Microbiology and Genetics, University of Göttingen, 37077 Göttingen, Germany.
Dominik GrontBiological and Chemical Research Center, Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.ORCID 0000-0002-2260-2083
Bridget Valeria Zinhle NkosiDepartment of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand, KwaDlangezwa 3886, South Africa.ORCID 0000-0002-3781-6076
David R NelsonDepartment of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0003-0583-5421
Khajamohiddin SyedDepartment of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand, KwaDlangezwa 3886, South Africa.ORCID 0000-0002-1497-3570
University of Zululand · ZAUniversity of KwaZulu-Natal · ZAUniversity of Göttingen · DEUniversity of Tennessee Health Science Center · USUniversity of Warsaw · PL

Funding

National Research Foundation (NRF), South Africa MND200527525406 and MND190606443406National Science Centre (Poland) 2018/29/B/ST6/01989University of Zululand C686
6 · The paper itself

Abstract

For the last six decades, cytochrome P450 monooxygenases (CYPs/P450s), heme thiolate proteins, have been under the spotlight due to their regio- and stereo-selective oxidation activities, which has led to the exploration of their applications in almost all known areas of biology. The availability of many genome sequences allows us to understand the evolution of P450s in different organisms, especially in the Bacteria domain. The phenomenon that "P450s play a key role in organisms' adaptation vis a vis lifestyle of organisms impacts P450 content in their genome" was proposed based on studies on a handful of individual bacterial groups. To have conclusive evidence, one must analyze P450s and their role in secondary metabolism in species with diverse lifestyles but that belong to the same category. We selected species of the phylum

Indexed as

BacteriaCytochrome P-450 Enzyme SystemPhylogenyProteobacteriaSecondary MetabolismCytochrome P-450 Enzyme SystemAlphaproteobacteriaBetaproteobacteriabiosynthetic gene-clustersDeltaproteobacteriadiversityEpsilonproteobacteriaevolutionGammaproteobacteriagenome-data miningP450ssecondary metabolism

Identifiers

PMID35628630
PMCPMC9148083
OpenAlexW4281291132

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.