Evidence map›Paper›PMID 35628615›Full record

ReviewInternational journal of molecular sciences2022

Intercellular Communication in the Central Nervous System as Deduced by Chemical Neuroanatomy and Quantitative Analysis of Images: Impact on Neuropharmacology.

Diego Guidolin, Cinzia Tortorella, Manuela Marcoli, Guido Maura, Luigi F Agnati

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. The auditory efferent system in mosquitoes.Frontiers in cell and developmental biology · 2023
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Diego GuidolinDepartment of Neuroscience, Section of Anatomy, University of Padova, 35121 Padova, Italy.ORCID 0000-0003-2133-3552
Cinzia TortorellaDepartment of Neuroscience, Section of Anatomy, University of Padova, 35121 Padova, Italy.
Manuela MarcoliDepartment of Pharmacy, Center of Excellence for Biomedical Research, University of Genova, 16126 Genova, Italy.
Guido MauraDepartment of Pharmacy, Center of Excellence for Biomedical Research, University of Genova, 16126 Genova, Italy.
Luigi F AgnatiDepartment of Biomedical Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
University of Genoa · ITUniversity of Padua · ITUniversity of Modena and Reggio Emilia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the last decades, new evidence on brain structure and function has been acquired by morphological investigations based on synergic interactions between biochemical anatomy approaches, new techniques in microscopy and brain imaging, and quantitative analysis of the obtained images. This effort produced an expanded view on brain architecture, illustrating the central nervous system as a huge network of cells and regions in which intercellular communication processes, involving not only neurons but also other cell populations, virtually determine all aspects of the integrative function performed by the system. The main features of these processes are described. They include the two basic modes of intercellular communication identified (i.e., wiring and volume transmission) and mechanisms modulating the intercellular signaling, such as cotransmission and allosteric receptor-receptor interactions. These features may also open new possibilities for the development of novel pharmacological approaches to address central nervous system diseases. This aspect, with a potential major impact on molecular medicine, will be also briefly discussed.

Indexed as

NeuroanatomyNeuropharmacologyCell CommunicationCentral Nervous SystemModels, Neurologicalcellular networkscotransmittershistochemistryimage analysisreceptor–receptor interactionsvolume transmission

Identifiers

PMID35628615
PMCPMC9145073
OpenAlexW4281263872

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.