SynthesisInternational journal of molecular sciences2022
Fascial Innervation: A Systematic Review of the Literature.
Synthesis in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 5 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- The effects of fascial manipulation on pain: a systematic review with meta-analysis.The Journal of manual & manipulative therapy · 2026Pooled it
- The stress-fascia-pain axis in myofascial pain syndrome: a mechanistic integrative review and conceptual synthesis.Frontiers in pain research (Lausanne, Switzerland) · 2026Pooled it
- Redefining Fascia: A Mechanobiological Hub and Stem Cell Reservoir in Regeneration-A Systematic Review.International journal of molecular sciences · 2025Pooled it
- The Prevalence and Risk Factors of Residual Back Pain After Vertebroplasty for Osteoporotic Vertebral Compression Fractures: A Systematic Review and Meta-Analysis.Orthopaedic surgery · 2025Pooled it
- Myofascial Release for the Treatment of Tension-Type, Cervicogenic Headache or Migraine: A Systematic Review and Meta-Analysis.Pain research & management · 2024Pooled it
- Trial
- Laparoscopic-guided transversus abdominis plane block combined with port-site infiltration for postoperative analgesia after gastric bypass: a randomized, double-blind, controlled trial.Surgical endoscopy · 2025Trial
- Low Back Pain in Cycling. Are There Differences between Road and Mountain Biking?International journal of environmental research and public health · 2023Trial
- Comparative Study of the Efficacy of Hyaluronic Acid, Dry Needling and Combined Treatment in Patellar Osteoarthritis-Single-Blind Randomized Clinical Trial.International journal of environmental research and public health · 2022Trial
- Bibliometric analysis of research hotspots and trends in fascia from 2013 to 2025.Surgical and radiologic anatomy : SRA · 2026Review
- Fascial Plane Blocks in Perioperative and Pain Medicine: From Mechanisms to Emerging Multitarget Interfascial Strategies.Current pain and headache reports · 2026Review
- Erector spinae plane block.BJA education · 2026Review
- Efficacy of Myofascial Release in Improving the Flexibility of Erector Spinae and Thoracolumbar Fascia in Subjects with Chronic Low Back Pain-A Sonoelastographic Analysis.International journal of therapeutic massage & bodywork · 2026Article
- Reply to Kiral, B.S. Ultrasonographic Evaluation of Superior Cluneal Nerve Entrapment: Methodological Considerations. Comment on "Iudicelli et al. The Role of Musculoskeletal Ultrasound in Detecting Superior Cluneal Nerve Entrapment: Biomechanical Insights in Chronic Low Back Pain-A Pilot Study.Diagnostics (Basel, Switzerland) · 2026Article
- Sciatic denervation differentially remodels skeletal muscle and deep fascia in the lower limb of male mice.Physiological reports · 2026Article
- Thoracolumbar Fascial Defect in Persistent Low Back Pain After Lumbar Surgery: Ultrasound Findings and Response to Fascial Plane Injection.Journal of orthopaedic case reports · 2026Article
- Cocktail injection with ropivacaine and compound betamethasone for preoperative thoracolumbar fascia injury effectively reduces postoperative pain and the risk of short-term postoperative residual pain during vertebral augmentation in the treatment of osteoporotic vertebral fractures: a retrospective controlled study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Fascia as a Functional System in Health and Disease: From Fundamental Biology to Assessment and Targeted Interventions.International journal of molecular sciences · 2026Review
- A systematic scoping review and conceptual analysis of new-onset fibromyalgia manifestations after non-hospitalized COVID-19: empirics, definitions, methodologies, pathophysiology, mapping of literature, and knowledge gaps.Journal of translational medicine · 2026Article
- [Effectiveness Analysis of Cervical Rotation-Traction Manipulation on Cervical and Dorsal Muscle Tone in Patients With Cervical Spondylotic Radiculopathy].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently, myofascial pain has become one of the main problems in healthcare systems. Research into its causes and the structures related to it may help to improve its management. Until some years ago, all the studies were focused on muscle alterations, as trigger points, but recently, fasciae are starting to be considered a new, possible source of pain. This systematic review has been conducted for the purpose of analyze the current evidence of the muscular/deep fasciae innervation from a histological and/or immunohistochemical point of view. A literature search published between 2000 and 2021 was made in PubMed and Google Scholar. Search terms included a combination of fascia, innervation, immunohistochemical, and different immunohistochemical markers. Of the 23 total studies included in the review, five studies were performed in rats, four in mice, two in horses, ten in humans, and two in both humans and rats. There were a great variety of immunohistochemical markers used to detect the innervation of the fasciae; the most used were Protein Gene Marker 9.5 (used in twelve studies), Calcitonin Gene-Related Peptide (ten studies), S100 (ten studies), substance P (seven studies), and tyrosine hydroxylase (six studies). Various areas have been studied, with the thoracolumbar fascia being the most observed. Besides, the papers highlighted diversity in the density and type of innervation in the various fasciae, going from free nerve endings to Pacini and Ruffini corpuscles. Finally, it has been observed that the innervation is increased in the pathological fasciae. From this review, it is evident that fasciae are well innerved, their innervation have a particular distribution and precise localization and is composed especially by proprioceptors and nociceptors, the latter being more numerous in pathological situations. This could contribute to a better comprehension and management of pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.