Evidence map›Paper›PMID 35628435›Full record

ArticleInternational journal of molecular sciences2022

Crassolide Induces G2/M Cell Cycle Arrest, Apoptosis, and Autophagy in Human Lung Cancer Cells via ROS-Mediated ER Stress Pathways.

Kuan-Ming Lai, Jou-Hsuan Wang, Shih-Chao Lin, Ya Wen, Chao-Liang Wu, Jui-Hsin Su, Chien-Chin Chen, Chi-Chien Lin

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. 8-O-acetylharpagide, an active compound isolated fromBiochemistry and biophysics reports · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Endoplasmic reticulum stress in non-small cell lung cancer.American journal of cancer research · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Kuan-Ming LaiProgram in Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan.
Jou-Hsuan WangInstitute of Biomedical Science, The iEGG and Animal Biotechnology Center, National Chung-Hsing University, Taichung 402, Taiwan.
Shih-Chao LinBachelor's Degree Program in Marine Biotechnology, College of Life Sciences, National Taiwan Ocean University, Keelung 202, Taiwan.ORCID 0000-0003-2942-5937
Ya WenDepartment of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Chao-Liang WuDepartment of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 600, Taiwan.ORCID 0000-0001-7821-9406
Jui-Hsin SuNational Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
Chien-Chin ChenDepartment of Pathology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 600, Taiwan.ORCID 0000-0001-9599-0884
Chi-Chien LinProgram in Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan.ORCID 0000-0002-1464-0231
Chia-Yi Christian Hospital · TWNational Chung Hsing University · TWAsia University · TWKarolinska Institutet · SENational Museum of Marine Biology and Aquarium · TWNational Taiwan Ocean University · TW

Funding

iEGG and Animal Biotechnology Center of the Feature Areas Research Center Program within the framework of the Higher Education Sprout Project by the Taiwan Ministry of Education (MOE-110-S-0023-ETaichung Veterans General Hospital TCVGH-1117307C
6 · The paper itself

Abstract

Crassolide, a cembranoid diterpene extracted from the soft coral

Indexed as

Carcinoma, Non-Small-Cell LungDiterpenesLung NeoplasmsApoptosisAutophagyCell Cycle CheckpointsCell Line, TumorG2 Phase Cell Cycle CheckpointsHumansReactive Oxygen SpeciescrassolideDiterpenesReactive Oxygen Speciesapoptosisautophagycell cyclecrassolideER stresslung cancerreactive oxygen speciessoft coral

Identifiers

PMID35628435
PMCPMC9144222
OpenAlexW4280630877

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.