Evidence map›Paper›PMID 35628399›Full record

ReviewInternational journal of molecular sciences2022

Osteosarcopenia: A Narrative Review on Clinical Studies.

Angela Polito, Lorenzo Barnaba, Donatella Ciarapica, Elena Azzini

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 5 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 5 syntheses or guidelines pooled it, 90 citations in OpenAlex.

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  9. Associations of muscle strength and functional power with longitudinal change in HR-pQCT bone parameters: the Osteoporotic Fractures in Men (MrOS) Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Angela PolitoCREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy.ORCID 0000-0003-4898-796X
Lorenzo BarnabaCREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy.
Donatella CiarapicaCREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy.ORCID 0000-0003-2428-416X
Elena AzziniCREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy.ORCID 0000-0002-1971-1668

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteosarcopenia (OS) is defined by the concurrent presence of osteopenia/osteoporosis and sarcopenia. The pathogenesis and etiology of OS involve genetic, biochemical, mechanical, and lifestyle factors. Moreover, an inadequate nutritional status, such as low intake of protein, vitamin D, and calcium, and a reduction in physical activity are key risk factors for OS. This review aims to increase knowledge about diagnosis, incidence, etiology, and treatment of OS through clinical studies that treat OS as a single disease. Clinical studies show the relationship between OS and the risk of frailty, falls, and fractures and some association with Non-communicable diseases (NCDs) pathologies such as diabetes, obesity, and cardiovascular disease. In some cases, the importance of deepening the related mechanisms is emphasized. Physical exercise with adequate nutrition and nutritional supplementations such as proteins, Vitamin D, or calcium, represent a significant strategy for breaking OS. In addition, pharmacological interventions may confer benefits on muscle and bone health. Both non-pharmacological and pharmacological interventions require additional randomized controlled trials (RCT) in humans to deepen the synergistic effect of exercise, nutritional interventions, and drug compounds in osteosarcopenia.

Indexed as

Bone Diseases, MetabolicOsteoporosisSarcopeniaCalciumCalcium, DietaryHumansVitamin DVitaminsCalciumCalcium, DietaryVitamin DVitaminsclinical studiesinterventionsosteosarcopenia

Identifiers

PMID35628399
PMCPMC9147376
OpenAlexW4280649138

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.