Evidence map›Paper›PMID 35628310›Full record

ArticleInternational journal of molecular sciences2022

Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome.

Xiaojing Mao, Zheng-Mei Xiong, Huijing Xue, Markus A Brown, Yantenew G Gete, Reynold Yu, Linlin Sun, Kan Cao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Genes · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Xiaojing MaoDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20817, USA.
Zheng-Mei XiongDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20817, USA.
Huijing XueDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20817, USA.
Markus A BrownDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20817, USA.ORCID 0000-0002-2069-0120
Yantenew G GeteDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20817, USA.
Reynold YuDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20817, USA.
Linlin SunDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20817, USA.
Kan CaoDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20817, USA.
University of Maryland, College Park · USNational Institutes of Health · US

Funding

Investigation of smooth muscle cell loss in progeriaR01HL126784 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI CAO, KAN · 2016 to 2020
$2.1M
NHLBI NIH HHS R01 HL126784NIH HHS RO1HL126784
6 · The paper itself

Abstract

Hutchinson-Gilford progeria syndrome (HGPS) is a detrimental premature aging disease caused by a point mutation in the human

Indexed as

Induced Pluripotent Stem CellsLymphoid Enhancer-Binding Factor 1ProgeriaCell DifferentiationHumansKeratinocytesLamin Type AWnt Signaling PathwayLamin Type ALEF1 protein, humanLymphoid Enhancer-Binding Factor 1epidermal developmentHGPSkeratinslamin ALEF1progeriaskinsWNT signaling

Identifiers

PMID35628310
PMCPMC9141373
OpenAlexW4280584177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.