Evidence map›Paper›PMID 35628296›Full record

ArticleInternational journal of molecular sciences2022

MicroPET Imaging Assessment of Brain Tau and Amyloid Deposition in 6 × Tg Alzheimer's Disease Model Mice.

ShinWoo Kang, Jinho Kim, Sang-Yoon Lee, Nobuyuki Okamura, Keun-A Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

ShinWoo KangDepartment of Pharmacology, College of Medicine, Gachon University, Incheon 21999, Korea.
Jinho KimNeuroscience Research Institute, Gachon University, Incheon 21565, Korea.ORCID 0000-0002-2631-5049
Sang-Yoon LeeNeuroscience Research Institute, Gachon University, Incheon 21565, Korea.
Nobuyuki OkamuraDivision of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai 980-8576, Japan.
Keun-A ChangDepartment of Pharmacology, College of Medicine, Gachon University, Incheon 21999, Korea.ORCID 0000-0002-6157-6340
Gachon University · KRTohoku Medical and Pharmaceutical University · JP

Funding

Korea Health Industry Development Institute HI14C1135National Research Foundation of Korea 2020M3A9E4104384
6 · The paper itself

Abstract

Alzheimer's disease (AD) is characterized by the deposition of extracellular amyloid plaques and intracellular accumulation of neurofibrillary tangles (NFT). Amyloid beta (Aβ) and tau imaging are widely used for diagnosing and monitoring AD in clinical settings. We evaluated the pathology of a recently developed 6 × Tg - AD (6 × Tg) mouse model by crossbreeding 5 × FAD mice with mice expressing mutant (P301L) tau protein using micro-positron emission tomography (PET) image analysis. PET studies were performed in these 6 × Tg mice using [

Indexed as

Alzheimer Diseasetau ProteinsAmyloid beta-PeptidesAniline CompoundsAnimalsBenzothiazolesBrainMicePositron-Emission TomographyRadiopharmaceuticalsTissue DistributionAmyloid beta-PeptidesAniline CompoundsBenzothiazolesflutemetamolRadiopharmaceuticalstau ProteinsAlzheimer’s diseaseDPA714FlutemetamolmicroPETMK6240THK5351

Identifiers

PMID35628296
PMCPMC9146140
OpenAlexW4280547631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.