Evidence map›Paper›PMID 35628229›Full record

ReviewInternational journal of molecular sciences2022

Probiotics Function in Preventing Atopic Dermatitis in Children.

Caterina Anania, Giulia Brindisi, Ivana Martinelli, Edoardo Bonucci, Miriam D'Orsi, Sara Ialongo, Anna Nyffenegger, Tonia Raso, Mattia Spatuzzo, Giovanna De Castro and 4 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

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  20. Potential Anti-Allergy and Immunomodulatory Properties ofJournal of microbiology and biotechnology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Caterina AnaniaDepartment of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, Italy.
Giulia BrindisiDepartment of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-5059-6082
Ivana MartinelliDepartment of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, Italy.
Edoardo BonucciDepartment of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, Italy.
Miriam D'OrsiDepartment of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, Italy.
Sara IalongoDepartment of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, Italy.
Anna NyffeneggerDepartment of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-2759-5019
Tonia RasoDepartment of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, Italy.
Mattia SpatuzzoDepartment of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, Italy.
Giovanna De CastroDepartment of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, Italy.
Anna Maria ZicariDepartment of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, Italy.
Carlo CarraroDepartment of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, Italy.
Maria Grazia PiccioniDepartment of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, Italy.
Francesca OliveroPediatric Clinic, Department of Pediatrics, Fondazione IRCSS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy.
Sapienza University of Rome · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by relapsing eczematous injuries and severe pruritus. In the last few years, the AD prevalence has been increasing, reaching 20% in children and 10% in adults in high-income countries. Recently, the potential role of probiotics in AD prevention has generated considerable interest. As many clinical studies show, the gut microbiota is able to modulate systemic inflammatory and immune responses influencing the development of sensitization and allergy. Probiotics are used increasingly against AD. However, the molecular mechanisms underlying the probiotics mediated anti-allergic effect remain unclear and there is controversy about their efficacy. In this narrative review, we examine the actual evidence on the effect of probiotic supplementation for AD prevention in the pediatric population, discussing also the potential biological mechanisms of action in this regard.

Indexed as

Dermatitis, AtopicGastrointestinal MicrobiomeHypersensitivityProbioticsAdultChildChronic DiseaseHumansSkinatopic dermatitischildrenpreventionprobiotics

Identifiers

PMID35628229
PMCPMC9141149
OpenAlexW4280585407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.