Evidence map›Paper›PMID 35627508›Full record

SynthesisInternational journal of environmental research and public health2022

Artificial Intelligence and Computer Aided Diagnosis in Chronic Low Back Pain: A Systematic Review.

Federico D'Antoni, Fabrizio Russo, Luca Ambrosio, Luca Bacco, Luca Vollero, Gianluca Vadalà, Mario Merone, Rocco Papalia, Vincenzo Denaro

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Artificial intelligence in pediatric pain: a systematic review.BMC medical informatics and decision making · 2026
    Pooled it
  2. Moving towards the use of artificial intelligence in pain management.European journal of pain (London, England) · 2025
    Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. MR Image Fusion-Based Parotid Gland Tumor Detection.Journal of imaging informatics in medicine · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Clinical Diagnosis and Treatment of Chronic Pain.Diagnostics (Basel, Switzerland) · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Federico D'AntoniUnit of Computer Systems and Bioinformatics, Università Campus Bio-Medico di Roma, Via Alvaro Del Portillo, 21, 00128 Rome, Italy.ORCID 0000-0001-7377-5462
Fabrizio RussoDepartment of Orthopaedic Surgery, Università Campus Bio-Medico di Roma, Via Alvaro Del Portillo, 200, 00128 Rome, Italy.ORCID 0000-0002-8566-8952
Luca AmbrosioDepartment of Orthopaedic Surgery, Università Campus Bio-Medico di Roma, Via Alvaro Del Portillo, 200, 00128 Rome, Italy.ORCID 0000-0003-2424-1274
Luca BaccoUnit of Computer Systems and Bioinformatics, Università Campus Bio-Medico di Roma, Via Alvaro Del Portillo, 21, 00128 Rome, Italy.ORCID 0000-0001-5462-2727
Luca VolleroUnit of Computer Systems and Bioinformatics, Università Campus Bio-Medico di Roma, Via Alvaro Del Portillo, 21, 00128 Rome, Italy.ORCID 0000-0002-6928-0157
Gianluca VadalàDepartment of Orthopaedic Surgery, Università Campus Bio-Medico di Roma, Via Alvaro Del Portillo, 200, 00128 Rome, Italy.ORCID 0000-0001-7142-1660
Mario MeroneUnit of Computer Systems and Bioinformatics, Università Campus Bio-Medico di Roma, Via Alvaro Del Portillo, 21, 00128 Rome, Italy.ORCID 0000-0002-9406-2397
Rocco PapaliaDepartment of Orthopaedic Surgery, Università Campus Bio-Medico di Roma, Via Alvaro Del Portillo, 200, 00128 Rome, Italy.
Vincenzo DenaroDepartment of Orthopaedic Surgery, Università Campus Bio-Medico di Roma, Via Alvaro Del Portillo, 200, 00128 Rome, Italy.
Università Campus Bio-Medico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low Back Pain (LBP) is currently the first cause of disability in the world, with a significant socioeconomic burden. Diagnosis and treatment of LBP often involve a multidisciplinary, individualized approach consisting of several outcome measures and imaging data along with emerging technologies. The increased amount of data generated in this process has led to the development of methods related to artificial intelligence (AI), and to computer-aided diagnosis (CAD) in particular, which aim to assist and improve the diagnosis and treatment of LBP. In this manuscript, we have systematically reviewed the available literature on the use of CAD in the diagnosis and treatment of chronic LBP. A systematic research of PubMed, Scopus, and Web of Science electronic databases was performed. The search strategy was set as the combinations of the following keywords: “Artificial Intelligence”, “Machine Learning”, “Deep Learning”, “Neural Network”, “Computer Aided Diagnosis”, “Low Back Pain”, “Lumbar”, “Intervertebral Disc Degeneration”, “Spine Surgery”, etc. The search returned a total of 1536 articles. After duplication removal and evaluation of the abstracts, 1386 were excluded, whereas 93 papers were excluded after full-text examination, taking the number of eligible articles to 57. The main applications of CAD in LBP included classification and regression. Classification is used to identify or categorize a disease, whereas regression is used to produce a numerical output as a quantitative evaluation of some measure. The best performing systems were developed to diagnose degenerative changes of the spine from imaging data, with average accuracy rates >80%. However, notable outcomes were also reported for CAD tools executing different tasks including analysis of clinical, biomechanical, electrophysiological, and functional imaging data. Further studies are needed to better define the role of CAD in LBP care.

Indexed as

Intervertebral Disc DegenerationLow Back PainArtificial IntelligenceComputersDiagnosis, Computer-AssistedHumansartificial intelligencecomputer aided diagnosisdecision support systemsdeep learninglow back painorthopaedics

Identifiers

PMID35627508
PMCPMC9141006
OpenAlexW4280525502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.