ReviewGenes2022
Inferring Signatures of Positive Selection in Whole-Genome Sequencing Data: An Overview of Haplotype-Based Methods.
Review in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Scientists' Warning on the Rapid Evolution of Parasites in the Anthropocene.Evolutionary applications · 2026Article
- Genetic variations of STAT3 gene and their role in hodgkin lymphoma incidence.Molecular biology reports · 2026Article
- Resolving sampling and population-size biases in domestication genomics supports a South Asian origin of walnuts.Genome biology · 2026Article
- Genomic scans for diversity and selection signatures in Indian Red Sindhi cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Study on the Genomic Basis of Adaptation in Salsk Sheep.Biology · 2025Article
- Selection Signatures in the Genome of Dzhalgin Merino Sheep Breed.Animals : an open access journal from MDPI · 2025Article
- A Genome-Wide Analysis of Structure and Evolution in Irish and British Populations ofEvolutionary applications · 2025Article
- The Evolution of Wisteria Vein Mosaic Virus: A Case Study Approach to Track the Emergence of New Potyvirus Threats.Pathogens (Basel, Switzerland) · 2024Article
- Next Generation Sequencing and Genetic Analyses Reveal Factors Driving Evolution of Sweetpotato Viruses in Uganda.Pathogens (Basel, Switzerland) · 2024Article
- Genomic Evolution and Selective Pressure Analysis of a Novel Porcine Sapovirus in Shanghai, China.Microorganisms · 2024Article
- Selection Signal Analysis Reveals Hainan Yellow Cattle Are Being Selectively Bred for Heat Tolerance.Animals : an open access journal from MDPI · 2024Article
- Comprehensive whole-genome resequencing unveils genetic diversity and selective signatures of the Xiangdong black goat.Frontiers in genetics · 2024Article
- iHDSel software: The price equation and the population stability index to detect genomic patterns compatible with selective sweeps. An example with SARS-CoV-2.Biology methods & protocols · 2024Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Signatures of positive selection in the genome are a characteristic mark of adaptation that can reveal an ongoing, recent, or ancient response to environmental change throughout the evolution of a population. New sources of food, climate conditions, and exposure to pathogens are only some of the possible sources of selective pressure, and the rise of advantageous genetic variants is a crucial determinant of survival and reproduction. In this context, the ability to detect these signatures of selection may pinpoint genetic variants that are responsible for a significant change in gene regulation, gene expression, or protein synthesis, structure, and function. This review focuses on statistical methods that take advantage of linkage disequilibrium and haplotype determination to reveal signatures of positive selection in whole-genome sequencing data, showing that they emerge from different descriptions of the same underlying event. Moreover, considerations are provided around the application of these statistics to different species, their suitability for ancient DNA, and the usefulness of discovering variants under selection for biomedicine and public health in an evolutionary medicine framework.
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