Evidence map›Paper›PMID 35627269›Full record

ArticleGenes2022

A New Computational Deconvolution Algorithm for the Analysis of Forensic DNA Mixtures with SNP Markers.

Yu Yin, Peng Zhang, Yu Xing

Abstract read
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yu YinDepartment of Forensic Medicine, Chongqing Medical University, #1 Yixueyuan Road, Chongqing 400016, China.
Peng ZhangDepartment of Forensic Medicine, Chongqing Medical University, #1 Yixueyuan Road, Chongqing 400016, China.
Yu XingDepartment of Forensic Medicine, Chongqing Medical University, #1 Yixueyuan Road, Chongqing 400016, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single nucleotide polymorphisms (SNPs) support robust analysis on degraded DNA samples. However, the development of a systematic method to interpret the profiles derived from the mixtures is less studied, and it remains a challenge due to the bi-allelic nature of SNP markers. To improve the discriminating power of SNPs, this study explored bioinformatic strategies to analyze mixtures. Then, computer-generated mixtures were produced using real-world massively parallel sequencing (MPS) data from the single samples processed with the Precision ID Identity Panel. Moreover, the values of the frequency of major allele reads (

Indexed as

DNA FingerprintingPolymorphism, Single NucleotideAlgorithmsBiomarkersDNAHumansSequence Analysis, DNABiomarkersDNAbioinformaticsDNA mixture deconvolutionforensic geneticsK-means clusteringmassively parallel sequencing (MPS)Precision ID Identity PanelSAMtoolssingle nucleotide polymorphism (SNP)

Identifiers

PMID35627269
PMCPMC9141285

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.