Evidence map›Paper›PMID 35627266›Full record

ArticleGenes2022

Single-Cell RNA-Seq Analysis Reveals Lung Epithelial Cell Type-Specific Responses to HDM and Regulation by Tet1.

Tao Zhu, Anthony P Brown, Lucy P Cai, Gerald Quon, Hong Ji

Open access · goldAbstract read
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Metabolites · 2026
    Article
  2. Article
  3. Review
  4. SilencingEnvironmental epigenetics · 2025
    Article
  5. Article
  6. Article
  7. The "epiTet" of Air Pollution: Epigenetic Regulation of Airway Inflammation by Tet1.International archives of allergy and immunology · 2023
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tao ZhuCalifornia National Primate Research Center, University of California, Davis, CA 95616, USA.ORCID 0000-0001-9622-2721
Anthony P BrownCalifornia National Primate Research Center, University of California, Davis, CA 95616, USA.ORCID 0000-0001-6100-2470
Lucy P CaiCalifornia National Primate Research Center, University of California, Davis, CA 95616, USA.
Gerald QuonDepartment of Molecular and Cellular Biology, Genome Center, University of California, Davis, CA 95616, USA.ORCID 0000-0002-1716-0153
Hong JiCalifornia National Primate Research Center, University of California, Davis, CA 95616, USA.ORCID 0000-0002-9558-0620
University of California, Davis · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Irva Hertz-Picciotto · 2015 to 2026
$26.0M
Role of TET1 in airway epithelium and childhood asthmaR01AI141569 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JI, HONG · 2019 to 2023
$3.0M
NIAID NIH HHS R01 AI141569NIEHS NIH HHS P30 ES023513NIH HHS P51 OD011107
6 · The paper itself

Abstract

Tet1 protects against house dust mite (HDM)-induced lung inflammation in mice and alters the lung methylome and transcriptome. In order to explore the role of Tet1 in individual lung epithelial cell types in HDM-induced inflammation, we established a model of HDM-induced lung inflammation in Tet1 knockout and littermate wild-type mice, then studied EpCAM

Indexed as

AsthmaDNA-Binding ProteinsPneumoniaProto-Oncogene ProteinsPyroglyphidaeAnimalsEpithelial Cell Adhesion MoleculeEpithelial CellsLungMiceMice, KnockoutSequence Analysis, RNASingle-Cell AnalysisDNA-Binding ProteinsEpithelial Cell Adhesion MoleculeProto-Oncogene ProteinsTET1 protein, mouseallergic lung inflammationalveolar type 2 (AT2) cellsciliated cellssingle-cell RNA-seqTet1

Identifiers

PMID35627266
PMCPMC9140484
OpenAlexW4280638871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.