Evidence map›Paper›PMID 35627253›Full record

ArticleGenes2022

A New Zebrafish Model to Measure Neuronal α-Synuclein Clearance In Vivo.

Ana Lopez, Alena Gorb, Nuno Palha, Angeleen Fleming, David C Rubinsztein

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Ana LopezCambridge Institute for Medical Research, Cambridge Biomedical Campus, The Keith Peters Building Cambridge, Hills Road, Cambridge CB2 0XY, UK.
Alena GorbDepartment of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.
Nuno PalhaNeuroscience and Immunoinflammation Therapeutic Area, Institut de Recherche Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, France.
Angeleen FlemingCambridge Institute for Medical Research, Cambridge Biomedical Campus, The Keith Peters Building Cambridge, Hills Road, Cambridge CB2 0XY, UK.ORCID 0000-0003-3721-7126
David C RubinszteinCambridge Institute for Medical Research, Cambridge Biomedical Campus, The Keith Peters Building Cambridge, Hills Road, Cambridge CB2 0XY, UK.
University of Cambridge · GBAVL (France) · FRUK Dementia Research Institute · GB

Funding

Medical Research Council UKDRI-2002
6 · The paper itself

Abstract

The accumulation and aggregation of α-synuclein (α-SYN) is a common characteristic of synucleinopathies, such as Parkinson's Disease (PD), Dementia with Lewy Bodies (DLB) or Multiple System Atrophy (MSA). Multiplications of the wildtype gene of α-SYN (

Indexed as

alpha-SynucleinSynucleinopathiesAnimalsKineticsNeuronsZebrafishalpha-Synucleinaggregationautophagyaxonal transportneurodegenerationParkinson’s diseaseprotein clearancezebrafish disease modelα-synuclein

Identifiers

PMID35627253
PMCPMC9141618
OpenAlexW4280612968

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.