Evidence map›Paper›PMID 35627056›Full record

ReviewFoods (Basel, Switzerland)2022

Lactose: Characteristics, Food and Drug-Related Applications, and Its Possible Substitutions in Meeting the Needs of People with Lactose Intolerance.

Simona Dominici, Francesca Marescotti, Chiara Sanmartin, Monica Macaluso, Isabella Taglieri, Francesca Venturi, Angela Zinnai, Maria Sole Facioni

Open access · goldAbstract readReview
In one paragraph

Review in Foods (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
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  8. Lactococcus lactis GV103, potentially probiotic, applied in the development of lactose-free fermented milk.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  9. Article
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  17. Complexities related to the amorphous content of lactose carriers.International journal of pharmaceutics: X · 2023
    Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Simona DominiciELLEFREE S.r.l., Polo Tecnologico Lucchese, 55100 Lucca, Italy.
Francesca MarescottiELLEFREE S.r.l., Polo Tecnologico Lucchese, 55100 Lucca, Italy.
Chiara SanmartinDepartment of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy.ORCID 0000-0002-7559-1955
Monica MacalusoDepartment of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy.
Isabella TaglieriDepartment of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy.ORCID 0000-0001-6000-9371
Francesca VenturiDepartment of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy.ORCID 0000-0002-7844-3253
Angela ZinnaiDepartment of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy.
Maria Sole FacioniAILI-Associazione Italiana Latto-Intolleranti Aps, 55100 Lucca, Italy.
University of Pisa · ITAssociazione Italiana Arbitri · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recent growing interest in lactose intolerance has resulted in the proliferation of lactose-free products by food manufacturing companies. Since updated papers about lactose and its uses are missing, the main purpose of this review is to investigate this sugar comprehensively. Firstly, its chemical and physical characteristics were studied, following its employment in the food and drug industries. The positive and negative health-related effects of lactose are reported, focusing on the condition of lactose intolerance, for which an adequate lactose-free diet has to be followed to avoid symptoms that impairs quality of life. Considering that EU legislation on lactose-free product labelling is still controversial, suitable options for producing and identifying lactose-free products are suggested, in order to meet lactose-intolerant people's needs.

Indexed as

chemical propertiesexcipientfood applicationlactoselactose-freelactose intolerancelegislation

Identifiers

PMID35627056
PMCPMC9141425
OpenAlexW4280540915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.