Evidence map›Paper›PMID 35626800›Full record

ArticleChildren (Basel, Switzerland)2022

Maternal Stress, Early Life Factors and Infant Salivary Cortisol Levels.

Caroline-Aleksi Olsson Mägi, Åshild Wik Despriee, Milada Cvancarova Småstuen, Catarina Almqvist, Fuad Bahram, Egil Bakkeheim, Anders Bjerg, Kari Glavin, Berit Granum, Guttorm Haugen and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Children (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 2 countries.

Caroline-Aleksi Olsson MägiDepartment of Women's and Children's Health, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID 0000-0002-5604-9132
Åshild Wik DesprieeFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, NO-0424 Oslo, Norway.
Milada Cvancarova SmåstuenFaculty of Health, VID Specialized University, NO-0424 Oslo, Norway.
Catarina AlmqvistAstrid Lindgren Children's Hospital, Karolinska University Hospital, SE-171 64 Stockholm, Sweden.
Fuad BahramResearch Centre, Stockholm South General Hospital, SE-118 83 Stockholm, Sweden.
Egil BakkeheimDivision of Paediatric and Adolescent Medicine, Oslo University Hospital, NO-0424 Oslo, Norway.
Anders BjergDepartment of Women's and Children's Health, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID 0000-0001-5723-6215
Kari GlavinFaculty of Health, VID Specialized University, NO-0424 Oslo, Norway.ORCID 0000-0002-6697-2764
Berit GranumDepartment of Chemical Toxicology, Norwegian Institute of Public Health, NO-0213 Oslo, Norway.
Guttorm HaugenFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, NO-0424 Oslo, Norway.
Gunilla HedlinDepartment of Women's and Children's Health, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Christine Monceyron JonassenFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, NO-1430 Ås, Norway.
Karin C Lødrup CarlsenFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, NO-0424 Oslo, Norway.
Eva Maria RehbinderDepartment of Dermatology and Vaenerology, Oslo University Hospital, NO-0424 Oslo, Norway.
Leif-Bjarte RolfsjordDivision of Paediatric and Adolescent Medicine, Oslo University Hospital, NO-0424 Oslo, Norway.ORCID 0000-0002-1149-3192
Anne Cathrine StaffFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, NO-0424 Oslo, Norway.
Håvard Ove SkjervenFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, NO-0424 Oslo, Norway.
Riyas VettukattilFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, NO-0424 Oslo, Norway.
Björn NordlundDepartment of Women's and Children's Health, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Cilla SöderhällDepartment of Women's and Children's Health, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID 0000-0002-8397-3080
Oslo University Hospital · NOKarolinska University Hospital · SEVID Specialized University · NOKarolinska Institutet · SENorwegian Institute of Public Health · NOØstfold Hospital Trust · NOStockholm South General Hospital · SEUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSalivary cortisol (SC), a commonly used biomarker for stress, may be disrupted by negative events in pregnancy, at birth and in infancy. We aimed to explore if maternal perceived stress (PSS) in or after pregnancy and SC levels in pregnancy were associated with SC in early infancy, and, secondly, to identify early life factors associated with infants' SC levels (iSC).

methodsAt 3 months of age, SC was analyzed in 1057 infants participating in a Nordic prospective mother-child birth cohort study. Maternal PSS was available from questionnaires at 18- and 34-week gestational age (GA) and 3-month post-partum, and SC was analyzed at 18-week GA. Early life factors included sociodemographic and infant feeding from questionnaires, and birth data from medical charts. Associations to iSC were analyzed by Spearman correlation and multinomial logistic regression analyses.

resultsIn this exploratory study neither PSS at any time point nor maternal SC (mSC) were associated with iSC. Higher birth weight was associated with higher levels of iSC, while inverse associations were observed in infants to a mother not living with a partner and mixed bottle/breastfeeding.

conclusionsMaternal stress was not associated with iSC levels, while birth weight, single motherhood and infant feeding may influence iSC levels.

Indexed as

infantperceived stressPreventADALLsalivary cortisol

Identifiers

PMID35626800
PMCPMC9139396
OpenAlexW4282919272

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.