Evidence map›Paper›PMID 35626721›Full record

ReviewCells2022

Transcribed Ultraconserved Regions in Cancer.

Myron K Gibert, Aditya Sarkar, Bilhan Chagari, Christian Roig-Laboy, Shekhar Saha, Sylwia Bednarek, Benjamin Kefas, Farina Hanif, Kadie Hudson, Collin Dube and 2 more

Abstract readReview
In one paragraph

Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Myron K GibertDepartment of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Aditya SarkarDepartment of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Bilhan ChagariDepartment of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Christian Roig-LaboyDepartment of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0003-0189-6542
Shekhar SahaDepartment of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0002-2797-3000
Sylwia BednarekDepartment of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Benjamin KefasDepartment of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Farina HanifDepartment of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Kadie HudsonDepartment of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Collin DubeDepartment of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Ying ZhangDepartment of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Roger AbounaderDepartment of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Dina Gould Halme · 1987 to 2026
$72.1M
Cancer Research Training Program: From Molecular Mechanisms to Therapeutic StrategiesT32CA009109 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Andrew Carl Dudley, Melanie R Rutkowski · 1985 to 2026
$13.9M
Master Regulatory MicroRNAs in GlioblastomaU01CA220841 · NCI · UNIVERSITY OF VIRGINIA · PI ABOUNADER, ROGER · 2017 to 2021
$2.5M
Calcium Channels in GlioblastomaR01NS122222 · NINDS · UNIVERSITY OF VIRGINIA · PI Roger Abounader · 2022 to 2026
$2.5M
Transcribed Ultra Conserved Regions in GlioblastomaR21NS122136 · NINDS · UNIVERSITY OF VIRGINIA · PI ABOUNADER, ROGER · 2021 to 2022
$444k
NCI NIH HHS P30 CA044579NCI NIH HHS T32 CA009109NCI NIH HHS U01 CA220841NINDS NIH HHS R01 NS122222NINDS NIH HHS R21 NS122136
6 · The paper itself

Abstract

Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. This is notable, as lncRNAs are typically poorly conserved. TUCRs remain very understudied in many diseases, including cancer. In this review, we summarize the current literature on TUCRs in cancer with respect to expression deregulation, functional roles, mechanisms of action, and clinical perspectives.

Indexed as

NeoplasmsRNA, Long NoncodingAnimalsConserved SequenceDNAGenomeMiceRatsDNARNA, Long Noncodingcancerlong non-coding RNATUCRultraconserved

Identifiers

PMID35626721
PMCPMC9139194

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.