Evidence map›Paper›PMID 35626674›Full record

ArticleCells2022

Group B Streptococcal Hemolytic Pigment Impairs Platelet Function in a Two-Step Process.

Kristin Jahn, Patience Shumba, Phoenicia Quach, Mathias Müsken, Jan Wesche, Andreas Greinacher, Lakshmi Rajagopal, Sven Hammerschmidt, Nikolai Siemens

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Kristin JahnCenter for Functional Genomics of Microbes, Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, 17489 Greifswald, Germany.ORCID 0000-0002-5090-1398
Patience ShumbaCenter for Functional Genomics of Microbes, Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, 17489 Greifswald, Germany.
Phoenicia QuachDepartment of Global Health, University of Washington, Seattle, WA 98105, USA.
Mathias MüskenCentral Facility for Microscopy, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.ORCID 0000-0002-5624-1378
Jan WescheDepartment of Transfusion Medicine, Institute of Immunology and Transfusion Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
Andreas GreinacherDepartment of Transfusion Medicine, Institute of Immunology and Transfusion Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.ORCID 0000-0001-8343-7336
Lakshmi RajagopalDepartment of Global Health, University of Washington, Seattle, WA 98105, USA.
Sven HammerschmidtCenter for Functional Genomics of Microbes, Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, 17489 Greifswald, Germany.ORCID 0000-0002-6382-6681
Nikolai SiemensCenter for Functional Genomics of Microbes, Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, 17489 Greifswald, Germany.
Universität Greifswald · DEUniversitätsmedizin Greifswald · DEHelmholtz Centre for Infection Research · DEInfectious Disease Research Institute · USUniversity of Washington · US

Funding

Immune Control of Group B Streptococcal PlacentalR01AI145890 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI ADAMS WALDORF, KRISTINA M., RAJAGOPAL, LAKSHMI · 2019 to 2023
$4.4M
FXIIIA production by mast cells for innate immunityR01AI152268 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI PILIPONSKY, ADRIAN M, RAJAGOPAL, LAKSHMI · 2020 to 2024
$3.7M
Role of an ornithine rhamnolipid pigment in GBS virulenceR01AI112619 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI RAJAGOPAL, LAKSHMI · 2014 to 2018
$2.4M
NIAID NIH HHS R01 AI112619NIAID NIH HHS R01 AI145890NIAID NIH HHS R01 AI152268
6 · The paper itself

Abstract

Group B streptococci (GBS) cause a range of invasive maternal-fetal diseases during pregnancy and post-partum. However, invasive infections in non-pregnant adults are constantly increasing. These include sepsis and streptococcal toxic shock syndrome, which are often complicated by systemic coagulation and thrombocytopenia. GBS express a hyper-hemolytic ornithine rhamnolipid pigment toxin with cytolytic and coagulatory activity. Here, we investigated the effects of GBS pigment on human platelets. Infections of platelets with pigmented GBS resulted initially in platelet activation, followed by necrotic cell death. Thus, this study shows that GBS pigment kills human platelets.

Indexed as

Streptococcal InfectionsStreptococcus agalactiaeAdultFemaleHemolysisHumansPigmentationPlatelet ActivationPregnancygroup B streptococcuspigmentplateletsStreptococcus agalactiae

Identifiers

PMID35626674
PMCPMC9139542
OpenAlexW4280494613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.