ArticleEntropy (Basel, Switzerland)2022
Probabilistic Inference with Polymerizing Biochemical Circuits.
Article in Entropy (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Aging as a Loss of Goal-Directedness: An Evolutionary Simulation and Analysis Unifying Regeneration with Anatomical Rejuvenation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The Multiscale Wisdom of the Body: Collective Intelligence as a Tractable Interface for Next-Generation Biomedicine.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Uncertainty minimization and pattern recognition inJournal of the Royal Society, Interface · 2025Article
- AI-driven automated discovery tools reveal diverse behavioral competencies of biological networks.eLife · 2025Article
- Collective intelligence: A unifying concept for integrating biology across scales and substrates.Communications biology · 2024Review
- Darwin's agential materials: evolutionary implications of multiscale competency in developmental biology.Cellular and molecular life sciences : CMLS · 2023Review
- A simple regulatory architecture allows learning the statistical structure of a changing environment.eLife · 2021Article
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Authors and funding
2 authors.
Funding
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Abstract
Probabilistic inference-the process of estimating the values of unobserved variables in probabilistic models-has been used to describe various cognitive phenomena related to learning and memory. While the study of biological realizations of inference has focused on animal nervous systems, single-celled organisms also show complex and potentially "predictive" behaviors in changing environments. Yet, it is unclear how the biochemical machinery found in cells might perform inference. Here, we show how inference in a simple Markov model can be approximately realized, in real-time, using polymerizing biochemical circuits. Our approach relies on assembling linear polymers that record the history of environmental changes, where the polymerization process produces molecular complexes that reflect posterior probabilities. We discuss the implications of realizing inference using biochemistry, and the potential of polymerization as a form of biological information-processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.