Evidence map›Paper›PMID 35626438›Full record

ArticleDiagnostics (Basel, Switzerland)2022

COVLIAS 1.0

Jasjit S Suri, Sushant Agarwal, Gian Luca Chabert, Alessandro Carriero, Alessio Paschè, Pietro S C Danna, Luca Saba, Armin Mehmedović, Gavino Faa, Inder M Singh and 31 more

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors at 20 institutions in 10 countries.

Jasjit S SuriStroke Diagnostic and Monitoring Division, AtheroPoint™, Roseville, CA 95661, USA.
Sushant AgarwalAdvanced Knowledge Engineering Centre, GBTI, Roseville, CA 95661, USA.ORCID 0000-0003-2360-3886
Gian Luca ChabertDepartment of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), 09124 Cagliari, Italy.ORCID 0000-0002-0005-5242
Alessandro CarrieroDepartment of Radiology, "Maggiore della Carità" Hospital, University of Piemonte Orientale (UPO), Via Solaroli 17, 28100 Novara, Italy.
Alessio PaschèDepartment of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), 09124 Cagliari, Italy.
Pietro S C DannaDepartment of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), 09124 Cagliari, Italy.
Luca SabaDepartment of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), 09124 Cagliari, Italy.
Armin MehmedovićUniversity Hospital for Infectious Diseases, 10000 Zagreb, Croatia.ORCID 0000-0002-5528-8051
Gavino FaaDepartment of Pathology, Azienda Ospedaliero Universitaria (A.O.U.), 09124 Cagliari, Italy.ORCID 0000-0002-0189-8612
Inder M SinghStroke Diagnostic and Monitoring Division, AtheroPoint™, Roseville, CA 95661, USA.
Monika TurkThe Hanse-Wissenschaftskolleg Institute for Advanced Study, 27753 Delmenhorst, Germany.
Paramjit S ChadhaStroke Diagnostic and Monitoring Division, AtheroPoint™, Roseville, CA 95661, USA.
Amer M JohriDepartment of Medicine, Division of Cardiology, Queen's University, Kingston, ON K7L 3N6, Canada.
Narendra N KhannaDepartment of Cardiology, Indraprastha APOLLO Hospitals, New Delhi 110076, India.
Sophie MavrogeniCardiology Clinic, Onassis Cardiac Surgery Center, 17674 Athens, Greece.
John R LairdHeart and Vascular Institute, Adventist Health St. Helena, St Helena, CA 94574, USA.
Gyan PareekMinimally Invasive Urology Institute, Brown University, Providence, RI 02912, USA.
Martin MinerMen's Health Center, Miriam Hospital, Providence, RI 02906, USA.
David W SobelMinimally Invasive Urology Institute, Brown University, Providence, RI 02912, USA.ORCID 0000-0002-0448-4765
Antonella BalestrieriDepartment of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), 09124 Cagliari, Italy.
Petros P SfikakisRheumatology Unit, National Kapodistrian University of Athens, 15772 Athens, Greece.
George TsoulfasDepartment of Surgery, Aristoteleion University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0001-5043-7962
Athanasios D ProtogerouCardiovascular Prevention and Research Unit, Department of Pathophysiology, National & Kapodistrian University of Athens, 15772 Athens, Greece.ORCID 0000-0002-3825-532X
Durga Prasanna MisraDepartment of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India.
Vikas AgarwalDepartment of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India.ORCID 0000-0002-4508-1233
George D KitasAcademic Affairs, Dudley Group NHS Foundation Trust, Dudley DY1 2HQ, UK.
Jagjit S TejiAnn and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA.
Mustafa Al-MainiAllergy, Clinical Immunology and Rheumatology Institute, Toronto, ON L4Z 4C4, Canada.
Surinder K DhanjilAtheroPoint LLC, Roseville, CA 95661, USA.
Andrew NicolaidesVascular Screening and Diagnostic Centre, University of Nicosia Medical School, Nicosia 2408, Cyprus.
Aditya SharmaDivision of Cardiovascular Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Vijay RathoreAtheroPoint LLC, Roseville, CA 95661, USA.
Mostafa FatemiDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.ORCID 0000-0002-6603-9077
Azra AlizadDepartment of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.ORCID 0000-0002-7658-1572
Pudukode R KrishnanNeurology Department, Fortis Hospital, Bangalore 560076, India.
Ferenc NagyInternal Medicine Department, University of Szeged, 6725 Szeged, Hungary.ORCID 0000-0003-3512-5850
Zoltan RuzsaInvasive Cardiology Division, University of Szeged, 6725 Szeged, Hungary.
Mostafa M FoudaDepartment of Electrical and Computer Engineering, Idaho State University, Pocatello, ID 83209, USA.ORCID 0000-0003-1790-8640
Subbaram NaiduElectrical Engineering Department, University of Minnesota, Duluth, MN 55812, USA.ORCID 0000-0001-8544-8397
Klaudija ViskovicUniversity Hospital for Infectious Diseases, 10000 Zagreb, Croatia.ORCID 0000-0002-5927-3201
Manudeep K KalraDepartment of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Azienda Ospedaliero-Universitaria Cagliari · ITBrown University · USMayo Clinic · USNational and Kapodistrian University of Athens · GRSanjay Gandhi Post Graduate Institute of Medical Sciences · INUniversity Hospital Centre Zagreb · HRUniversity of Szeged · HUAristotle University of Thessaloniki · GRDudley Group NHS Foundation Trust · GBFortis Hospital · INIdaho State University · USInstitute for Advanced Study · DELurie Children's Hospital · USMassachusetts General Hospital · USOnassis Cardiac Surgery Center · GRProvidence College · USQueen's University · CASt. Helena Hospital · USUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Minnesota, Duluth · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: COVID-19 is a disease with multiple variants, and is quickly spreading throughout the world. It is crucial to identify patients who are suspected of having COVID-19 early, because the vaccine is not readily available in certain parts of the world. Methodology: Lung computed tomography (CT) imaging can be used to diagnose COVID-19 as an alternative to the RT-PCR test in some cases. The occurrence of ground-glass opacities in the lung region is a characteristic of COVID-19 in chest CT scans, and these are daunting to locate and segment manually. The proposed study consists of a combination of solo deep learning (DL) and hybrid DL (HDL) models to tackle the lesion location and segmentation more quickly. One DL and four HDL models—namely, PSPNet, VGG-SegNet, ResNet-SegNet, VGG-UNet, and ResNet-UNet—were trained by an expert radiologist. The training scheme adopted a fivefold cross-validation strategy on a cohort of 3000 images selected from a set of 40 COVID-19-positive individuals. Results: The proposed variability study uses tracings from two trained radiologists as part of the validation. Five artificial intelligence (AI) models were benchmarked against MedSeg. The best AI model, ResNet-UNet, was superior to MedSeg by 9% and 15% for Dice and Jaccard, respectively, when compared against MD 1, and by 4% and 8%, respectively, when compared against MD 2. Statistical tests—namely, the Mann−Whitney test, paired t-test, and Wilcoxon test—demonstrated its stability and reliability, with p < 0.0001. The online system for each slice was <1 s. Conclusions: The AI models reliably located and segmented COVID-19 lesions in CT scans. The COVLIAS 1.0Lesion lesion locator passed the intervariability test.

Indexed as

computed tomographyCOVID-19COVID lesionsground-glass opacitieshybrid deep learningsegmentation

Identifiers

PMID35626438
PMCPMC9141749
OpenAlexW4281251645

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.