ReviewDiagnostics (Basel, Switzerland)2022
Diagnosis of Central Sensitization and Its Effects on Postoperative Outcomes following Total Knee Arthroplasty: A Systematic Review and Meta-Analysis.
Review in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 35 citations in OpenAlex.
- Preoperative education on realistic expectations improves the satisfaction of patients with central sensitization after total knee arthroplasty: a randomized-controlled trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Trial
- Preoperative Anxiety and Depression Are Associated with Lateral Compartment Osteoarthritis Progression After Medial Unicompartmental Knee Arthroplasty: A Retrospective Observational Cohort Study.Journal of clinical medicine · 2026Article
- Meditations on Methodological Issues in Clinical Investigations of "Central Sensitization" (Jonah XII).Journal of clinical medicine · 2026Article
- Metformin Use Is Associated With Reduced Inflammation and Pain After Total Knee Arthroplasty in Patients With Type 2 Diabetes.Orthopaedic surgery · 2026Article
- The Prevalence of Complex Regional Pain Syndrome after Primary Total Knee Arthroplasty - A Longitudinal Study.Journal of orthopaedic case reports · 2026Article
- Development of a clinical prediction model for chronic post-surgical shoulder pain following arthroscopic rotator cuff repair: A prospective cohort study.Shoulder & elbow · 2026Article
- Prevalence and Association of Neuropathic Pain and Central Sensitization in Participants with Knee Osteoarthritis: Establishing a Cutoff Score for the Central Sensitization Inventory.Journal of pain research · 2026Article
- Is There a Difference in Factors Affecting Rest Pain and Pain Intensity during Movement at 1 Year Post-total Knee Arthroplasty?Physical therapy research · 2026Article
- The impact of central sensitization on perioperative pain in TKA: a retrospective cohort study.Knee surgery & related research · 2025Article
- Transcranial direct current stimulation alleviates the pain severity in people suffering from knee osteoarthritis: a systematic review and meta-analysis.Pain reports · 2025Review
- A Mediation Appraisal of Neuropathic-like Symptoms, Pain Catastrophizing, and Central Sensitization-Related Signs in Adults with Knee Osteoarthritis-A Cross-Sectional Study.Journal of personalized medicine · 2025Article
- Prevalence of central sensitisation associated symptoms and associations with treatment outcomes in surgical, interventional and injection-based treatment for patients with chronic spinal pain.SAGE open medicine · 2025Article
- Description of pain associated with persistent postoperative pain after total knee arthroplasty.Scientific reports · 2024Article
- Does pain intensity after total knee arthroplasty depend on somatosensory functioning in knee osteoarthritis patients? A prospective cohort study.Clinical rheumatology · 2024Article
- Mechanisms and Preventative Strategies for Persistent Pain following Knee and Hip Joint Replacement Surgery: A Narrative Review.International journal of molecular sciences · 2024Review
- Does central sensitization correlate with two-year postoperative functional outcome scores following hip arthroscopy?Journal of orthopaedics · 2024Article
- Pain Catastrophizing and Acute Post-Surgical Pain in Knee Arthroplasty Patients: The Moderating Role of Social Support.Journal of pain research · 2024Article
- Cross-cultural adaptation and validation for central sensitization inventory: based on Chinese patients undergoing total knee arthroplasty for knee osteoarthritis.Journal of orthopaedic surgery and research · 2023Article
- Low central sensitisation inventory score is associated with better post-operative outcomes of osteotomy around the knee.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- Prognostic Factors for Postoperative Chronic Pain after Knee or Hip Replacement in Patients with Knee or Hip Osteoarthritis: An Umbrella Review.Journal of clinical medicine · 2023Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Central sensitization (CS) has been extensively researched as a cause of persistent pain after total knee arthroplasty (TKA). This systematic review study sought to investigate the diagnosis of CS in patients who underwent TKA for knee osteoarthritis (OA) and the effect of CS on clinical outcomes after TKA. Three comprehensive databases, including MEDLINE, EMBASE, and the Cochrane Library, were searched for studies that evaluated the outcomes of TKA in knee OA patients with CS. Data extraction, risk of bias assessment, and (where appropriate) meta-analysis were performed. The standardized mean difference (SMD) with a 95% confidence interval was used to assess the different scales of pain. A total of eight studies were selected, including two retrospective studies and five prospective observational studies. One study used additional randomized controlled trial data. Five studies were finally included in the meta-analysis. All studies had a minimum follow-up period of 3 months. The Central Sensitization Inventory (CSI), whole-body pain diagram, and quantitative sensory testing (QST) were used for measuring CS. The pooled analysis showed that patients with CS had more severe postoperative pain after TKA (SMD, 0.65; 95% CI, 0.40−0.90; p < 0.01) with moderate heterogeneity (I2 = 60%). In patients who underwent TKA with knee OA, CSI is most often used for the diagnosis of CS, and the QST and whole-body pain diagram are also used. CS is closely associated with more severe and persistent pain after TKA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.