Evidence map›Paper›PMID 35626389›Full record

ReviewDiagnostics (Basel, Switzerland)2022

Cardiovascular Risk Stratification in Diabetic Retinopathy via Atherosclerotic Pathway in COVID-19/Non-COVID-19 Frameworks Using Artificial Intelligence Paradigm: A Narrative Review.

Smiksha Munjral, Mahesh Maindarkar, Puneet Ahluwalia, Anudeep Puvvula, Ankush Jamthikar, Tanay Jujaray, Neha Suri, Sudip Paul, Rajesh Pathak, Luca Saba and 38 more

Open access · goldAbstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors at 20 institutions in 10 countries.

Smiksha MunjralStroke Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA 95661, USA.ORCID 0000-0002-1941-8357
Mahesh MaindarkarStroke Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA 95661, USA.
Puneet AhluwaliaMax Institute of Cancer Care, Max Super Specialty Hospital, New Delhi 110017, India.
Anudeep PuvvulaStroke Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA 95661, USA.
Ankush JamthikarStroke Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA 95661, USA.
Tanay JujarayStroke Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA 95661, USA.
Neha SuriMira Loma High School, Sacramento, CA 95821, USA.
Sudip PaulDepartment of Biomedical Engineering, North Eastern Hill University, Shillong 793022, India.ORCID 0000-0001-9856-539X
Rajesh PathakDepartment of Computer Science Engineering, Rawatpura Sarkar University, Raipur 492015, India.
Luca SabaDepartment of Radiology, Azienda Ospedaliero Universitaria, 40138 Cagliari, Italy.
Renoh Johnson ChalakkaloDocs Eye Care Research Laboratory, Dunedin 9013, New Zealand.ORCID 0000-0003-3452-5633
Suneet GuptaCSE Department, Bennett University, Greater Noida 201310, India.
Gavino FaaDepartment of Pathology, Azienda Ospedaliero Universitaria, 09124 Cagliari, Italy.ORCID 0000-0002-0189-8612
Inder M SinghStroke Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA 95661, USA.
Paramjit S ChadhaStroke Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA 95661, USA.
Monika TurkThe Hanse-Wissenschaftskolleg Institute for Advanced Study, 27753 Delmenhorst, Germany.
Amer M JohriDepartment of Medicine, Division of Cardiology, Queen's University, Kingston, ON K7L 3N6, Canada.
Narendra N KhannaDepartment of Cardiology, Indraprastha APOLLO Hospitals, New Delhi 110001, India.
Klaudija ViskovicDepartment of Radiology and Ultrasound, University Hospital for Infectious Diseases, 10 000 Zagreb, Croatia.ORCID 0000-0002-5927-3201
Sophie MavrogeniCardiology Clinic, Onassis Cardiac Surgery Centre, 17674 Athens, Greece.
John R LairdHeart and Vascular Institute, Adventist Health St. Helena, St. Helena, CA 94574, USA.
Gyan PareekMinimally Invasive Urology Institute, Brown University, Providence, RI 02912, USA.
Martin MinerMen's Health Centre, Miriam Hospital Providence, Providence, RI 02906, USA.
David W SobelRheumatology Unit, National Kapodistrian University of Athens, 15772 Athens, Greece.ORCID 0000-0002-0448-4765
Antonella BalestrieriDepartment of Radiology, Azienda Ospedaliero Universitaria, 40138 Cagliari, Italy.
Petros P SfikakisRheumatology Unit, National Kapodistrian University of Athens, 15772 Athens, Greece.
George TsoulfasDepartment of Surgery, Aristoteleion University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0001-5043-7962
Athanasios ProtogerouCardiovascular Prevention and Research Unit, Department of Pathophysiology, National & Kapodistrian University of Athens, 15772 Athens, Greece.ORCID 0000-0002-3825-532X
Durga Prasanna MisraDepartment of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India.
Vikas AgarwalDepartment of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India.ORCID 0000-0002-4508-1233
George D KitasAcademic Affairs, Dudley Group NHS Foundation Trust, Dudley DY1 2HQ, UK.
Raghu KolluriOhioHealth Heart and Vascular, Columbus, OH 43214, USA.
Jagjit TejiAnn and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA.
Mustafa Al-MainiAllergy, Clinical Immunology and Rheumatology Institute, Toronto, ON L4Z 4C4, Canada.
Surinder K DhanjilStroke Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA 95661, USA.
Meyypan SockalingamMV Centre of Diabetes, Chennai 600013, India.
Ajit SaxenaDepartment of Cardiology, Indraprastha APOLLO Hospitals, New Delhi 110001, India.
Aditya SharmaDivision of Cardiovascular Medicine, University of Virginia, Charlottesville, VA 22904, USA.
Vijay RathoreNephrology Department, Kaiser Permanente, Sacramento, CA 95119, USA.
Mostafa FatemiDepartment of Physiology & Biomedical Engineering, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.ORCID 0000-0002-6603-9077
Azra AlizadDepartment of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Vijay ViswanathanMV Hospital for Diabetes and Professor MVD Research Centre, Chennai 600013, India.
Padukode R KrishnanNeurology Department, Fortis Hospital, Bangalore 560076, India.
Tomaz OmerzuDepartment of Neurology, University Medical Centre Maribor, 1262 Maribor, Slovenia.
Subbaram NaiduElectrical Engineering Department, University of Minnesota, Duluth, MN 55812, USA.ORCID 0000-0001-8544-8397
Andrew NicolaidesVascular Screening and Diagnostic Centre, University of Nicosia Medical School, Nicosia 2408, Cyprus.
Mostafa M FoudaDepartment of Electrical and Computer Engineering, Idaho State University, Pocatello, ID 83209, USA.ORCID 0000-0003-1790-8640
Jasjit S SuriStroke Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA 95661, USA.
Azienda Ospedaliero-Universitaria Cagliari · ITNational and Kapodistrian University of Athens · GRMayo Clinic · USM.V. Hospital for Diabetes and Diabetes Research Centre · INNorth Eastern Hill University · INSanjay Gandhi Post Graduate Institute of Medical Sciences · INAnna University, Chennai · INAristotle University of Thessaloniki · GRBennett University · INBrown University · USDudley Group NHS Foundation Trust · GBFortis Hospital · INIdaho State University · USInstitute for Advanced Study · DEKaiser Permanente · USLurie Children's Hospital · USMax Super Speciality Hospital · INOhioHealth · USOnassis Cardiac Surgery Center · GRPandit Ravishankar Shukla University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes is one of the main causes of the rising cases of blindness in adults. This microvascular complication of diabetes is termed diabetic retinopathy (DR) and is associated with an expanding risk of cardiovascular events in diabetes patients. DR, in its various forms, is seen to be a powerful indicator of atherosclerosis. Further, the macrovascular complication of diabetes leads to coronary artery disease (CAD). Thus, the timely identification of cardiovascular disease (CVD) complications in DR patients is of utmost importance. Since CAD risk assessment is expensive for low-income countries, it is important to look for surrogate biomarkers for risk stratification of CVD in DR patients. Due to the common genetic makeup between the coronary and carotid arteries, low-cost, high-resolution imaging such as carotid B-mode ultrasound (US) can be used for arterial tissue characterization and risk stratification in DR patients. The advent of artificial intelligence (AI) techniques has facilitated the handling of large cohorts in a big data framework to identify atherosclerotic plaque features in arterial ultrasound. This enables timely CVD risk assessment and risk stratification of patients with DR. Thus, this review focuses on understanding the pathophysiology of DR, retinal and CAD imaging, the role of surrogate markers for CVD, and finally, the CVD risk stratification of DR patients. The review shows a step-by-step cyclic activity of how diabetes and atherosclerotic disease cause DR, leading to the worsening of CVD. We propose a solution to how AI can help in the identification of CVD risk. Lastly, we analyze the role of DR/CVD in the COVID-19 framework.

Indexed as

artificial intelligenceatherosclerosiscardiovascular diseasediabetic retinopathyrisk assessmentrisk stratificationsurrogate biomarkers

Identifiers

PMID35626389
PMCPMC9140106
OpenAlexW4280557296

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.