Evidence map›Paper›PMID 35626356›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Clinical and Imaging Features of COVID-19-Associated Pulmonary Aspergillosis.

Tim Fischer, Yassir El Baz, Nicole Graf, Simon Wildermuth, Sebastian Leschka, Gian-Reto Kleger, Urs Pietsch, Manuel Frischknecht, Giulia Scanferla, Carol Strahm and 3 more

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Tim FischerDivision of Radiology and Nuclear Medicine, St. Gallen Cantonal Hospital, 9007 St. Gallen, Switzerland.ORCID 0000-0002-1807-9146
Yassir El BazDivision of Radiology and Nuclear Medicine, St. Gallen Cantonal Hospital, 9007 St. Gallen, Switzerland.ORCID 0000-0002-4729-1226
Nicole GrafClinical Trials Unit, St. Gallen Cantonal Hospital, 9007 St. Gallen, Switzerland.
Simon WildermuthDivision of Radiology and Nuclear Medicine, St. Gallen Cantonal Hospital, 9007 St. Gallen, Switzerland.
Sebastian LeschkaDivision of Radiology and Nuclear Medicine, St. Gallen Cantonal Hospital, 9007 St. Gallen, Switzerland.
Gian-Reto KlegerDivision of Intensive Care, St. Gallen Cantonal Hospital, 9007 St. Gallen, Switzerland.
Urs PietschDepartment of Anesthesia, Intensive Care, Emergency and Pain Medicine, St. Gallen Cantonal Hospital, 9007 St. Gallen, Switzerland.ORCID 0000-0001-6957-2638
Manuel FrischknechtDivision of Infectious Diseases and Hospital Epidemiology, St. Gallen Cantonal Hospital, 9007 St. Gallen, Switzerland.ORCID 0000-0002-8291-6359
Giulia ScanferlaDivision of Infectious Diseases and Hospital Epidemiology, St. Gallen Cantonal Hospital, 9007 St. Gallen, Switzerland.
Carol StrahmDivision of Infectious Diseases and Hospital Epidemiology, St. Gallen Cantonal Hospital, 9007 St. Gallen, Switzerland.
Stephan WältiDivision of Radiology and Nuclear Medicine, St. Gallen Cantonal Hospital, 9007 St. Gallen, Switzerland.
Tobias Johannes DietrichDivision of Radiology and Nuclear Medicine, St. Gallen Cantonal Hospital, 9007 St. Gallen, Switzerland.ORCID 0000-0003-2979-6471
Werner C AlbrichDivision of Infectious Diseases and Hospital Epidemiology, St. Gallen Cantonal Hospital, 9007 St. Gallen, Switzerland.ORCID 0000-0003-0607-7159
University of St.Gallen · CHKantonsspital St. Gallen · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCOVID-19 superinfection by Aspergillus (COVID-19-associated aspergillosis, CAPA) is increasingly observed due to increased awareness and use of corticosteroids. The aim of this study is to compare clinical and imaging features between COVID-19 patients with and without associated pulmonary aspergillosis. MATERIAL AND

methodsIn this case-control study, hospitalized patients between March 2020 and March 2021 were evaluated. Two observers independently compared 105 chest CTs of 52 COVID-19 patients without pulmonary aspergillosis to 40 chest CTs of 13 CAPA patients. The following features were evaluated: lung involvement, predominant main pattern (ground glass opacity, crazy paving, consolidation) and additional lung and chest findings. Chronological changes in the abnormal extent upon CT and chronological changes in the main patterns were compared with mixed models. Patient-wise comparisons of additional features and demographic and clinical data were performed using Student's t-test, Chi-squared test, Fisher's exact tests and Wilcoxon rank-sum tests.

resultsCompared to COVID-19 patients without pulmonary aspergillosis, CAPA patients were older (mean age (±SD): 70.3 (±7.8) versus 63.5 (±9.5) years (

conclusionsCAPA patients showed a tendency for consolidation in early COVID-19 disease. Bronchial wall thickening and higher patient age were associated with CAPA. The overall lung involvement was similar between both groups.

Indexed as

chest CTCOVID-19COVID-19-associated pulmonary aspergillosis

Identifiers

PMID35626356
PMCPMC9140144
OpenAlexW4280536859

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.