Evidence map›Paper›PMID 35626319›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Factors Associated with False Negative Results in Serum Pepsinogen Testing for Precancerous Gastric Lesions in a European Population in the GISTAR Study.

Danute Razuka-Ebela, Inese Polaka, Ilva Daugule, Sergei Parshutin, Daiga Santare, Inguna Ebela, Dace Rudzite, Reinis Vangravs, Rolando Herrero, Jin Young Park and 1 more

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Gastric Mucosa Cancer Risk: The Operative Link on Gastritis Assessment Staging System.The Korean journal of helicobacter and upper gastrointestinal research · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Danute Razuka-EbelaFaculty of Medicine, University of Latvia, Jelgavas iela 3, LV-1004 Riga, Latvia.ORCID 0000-0002-3069-0140
Inese PolakaInstitute of Clinical and Preventive Medicine, University of Latvia, Jelgavas iela 3, LV-1004 Riga, Latvia.ORCID 0000-0002-9892-7765
Ilva DauguleFaculty of Medicine, University of Latvia, Jelgavas iela 3, LV-1004 Riga, Latvia.
Sergei ParshutinInstitute of Clinical and Preventive Medicine, University of Latvia, Jelgavas iela 3, LV-1004 Riga, Latvia.ORCID 0000-0002-8689-3043
Daiga SantareFaculty of Medicine, University of Latvia, Jelgavas iela 3, LV-1004 Riga, Latvia.
Inguna EbelaFaculty of Medicine, University of Latvia, Jelgavas iela 3, LV-1004 Riga, Latvia.
Dace RudziteInstitute of Clinical and Preventive Medicine, University of Latvia, Jelgavas iela 3, LV-1004 Riga, Latvia.
Reinis VangravsInstitute of Clinical and Preventive Medicine, University of Latvia, Jelgavas iela 3, LV-1004 Riga, Latvia.
Rolando HerreroInternational Agency for Research on Cancer, 150 Cours Albert Thomas, CEDEX 08, 69372 Lyon, France.
Jin Young ParkInternational Agency for Research on Cancer, 150 Cours Albert Thomas, CEDEX 08, 69372 Lyon, France.ORCID 0000-0003-2491-5099
Marcis LejaFaculty of Medicine, University of Latvia, Jelgavas iela 3, LV-1004 Riga, Latvia.ORCID 0000-0002-0319-8855
University of Latvia · LVCentre international de recherche sur le cancer · FRInstituto Costarricense de Investigación y Enseñanza en Nutrición y Salud · CRRiga East University Hospital · LV

Funding

World Health Organization 001
6 · The paper itself

Abstract

The accuracy of plasma pepsinogen (Pg) as a marker for precancerous gastric lesions (PGL) has shown variable results. We aimed to identify factors associated with false negative (FN) cases in Pg testing and to adjust cut-off values for these factors in order to improve Pg yield. Plasma Pg was measured and upper endoscopy with biopsy was performed within the "Multicentric randomized study of

Indexed as

GISTARHelicobacter pyloriLatviapepsinogenprecancerous gastric lesionssensitivitysmoking

Identifiers

PMID35626319
PMCPMC9139962
OpenAlexW4229333758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.