ArticleDiagnostics (Basel, Switzerland)2022
Prognostic Value of Perineural Invasion on Survival and Recurrence in Oral Squamous Cell Carcinoma.
Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Southern Iran tertiary-center validation of 5-year disease free survival and overall survival rates in tongue squamous cell carcinoma: a confirmatory retrospective 10-years cohort study.BMC oral health · 2026Article
- Postoperative Adjuvant Therapy in Resectable Advanced Oral Squamous Cell Carcinoma With Intermediate Risk Factors.Head & neck · 2026Article
- Article
- Grading systems and perineural invasion in oral squamous cell carcinoma - a disease-specific survival analysis.Medicina oral, patologia oral y cirugia bucal · 2025Article
- Impact of CD68, CD4, TNF-α, and COX-2 expression on disease-specific survival in Brazilian patients with OSCC.Brazilian oral research · 2025Article
- Review
- Personalized Medicine in Oral Oncology: Imaging Methods and Biological Markers to Support Diagnosis of Oral Squamous Cell Carcinoma (OSCC): A Narrative Literature Review.Journal of personalized medicine · 2023Review
- Multimodality Imaging Assessment of Desmoid Tumors: The Great Mime in the Era of Multidisciplinary Teams.Journal of personalized medicine · 2022Review
- Diagnostic accuracy of perineural invasion in oral squamous cell carcinoma is improved by immunohistochemistry and correlates with locoregional recurrence.Journal of oral and maxillofacial pathology : JOMFPArticle
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
A diagnosis of perineural invasion (PNI) is widely accepted as an unfavorable prognostic factor in various solid malignancies. Although PNI has been described as a high-risk parameter in oral squamous cell carcinoma (OSCC), its role in the current staging manuals of the American Joint Committee on Cancer (AJCC) is rather subordinate. We analysed the prognostic value of PNI on survival and recurrence in a large, multicenter OSCC cohort and a population-based approach. A total of 493 OSCC patients with primary tumor resection to negative margins and concomitant neck dissection between 2010 and 2017 were enrolled. PNI was evaluated in relation to overall survival (OAS) and recurrence-free survival (RFS) using uni- and multi-variable Cox regression. The median follow-up time was 5.0 years and PNI was diagnosed in 48 patients (9.7%). A pathohistological verification of PNI correlated significantly with a deteriorated OAS in uni- (HR 2.312; 95% CI 2.312-3.493,
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Registered trials
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