Evidence map›Paper›PMID 35626093›Full record

ArticleCancers2022

iMIL4PATH: A Semi-Supervised Interpretable Approach for Colorectal Whole-Slide Images.

Pedro C Neto, Sara P Oliveira, Diana Montezuma, João Fraga, Ana Monteiro, Liliana Ribeiro, Sofia Gonçalves, Isabel M Pinto, Jaime S Cardoso

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Pedro C NetoInstitute for Systems and Computer Engineering, Technology and Science (INESC TEC), 4200-465 Porto, Portugal.ORCID 0000-0003-1333-4889
Sara P OliveiraInstitute for Systems and Computer Engineering, Technology and Science (INESC TEC), 4200-465 Porto, Portugal.ORCID 0000-0002-6586-9079
Diana MontezumaIMP Diagnostics, 4150-146 Porto, Portugal.ORCID 0000-0001-9551-4589
João FragaDepartment of Pathology, IPO-Porto, 4200-072 Porto, Portugal.
Ana MonteiroIMP Diagnostics, 4150-146 Porto, Portugal.
Liliana RibeiroIMP Diagnostics, 4150-146 Porto, Portugal.
Sofia GonçalvesIMP Diagnostics, 4150-146 Porto, Portugal.
Isabel M PintoIMP Diagnostics, 4150-146 Porto, Portugal.
Jaime S CardosoInstitute for Systems and Computer Engineering, Technology and Science (INESC TEC), 4200-465 Porto, Portugal.ORCID 0000-0002-3760-2473
Universidade do Porto · PTIPO Porto · PT

Funding

European Commission POCI-01-0247-FEDER-045413Fundação para a Ciência e Tecnologia 2021.06872.BDFundação para a Ciência e Tecnologia SFRH/BD/139108/2018
6 · The paper itself

Abstract

Colorectal cancer (CRC) diagnosis is based on samples obtained from biopsies, assessed in pathology laboratories. Due to population growth and ageing, as well as better screening programs, the CRC incidence rate has been increasing, leading to a higher workload for pathologists. In this sense, the application of AI for automatic CRC diagnosis, particularly on whole-slide images (WSI), is of utmost relevance, in order to assist professionals in case triage and case review. In this work, we propose an interpretable semi-supervised approach to detect lesions in colorectal biopsies with high sensitivity, based on multiple-instance learning and feature aggregation methods. The model was developed on an extended version of the recent, publicly available CRC dataset (the CRC+ dataset with 4433 WSI), using 3424 slides for training and 1009 slides for evaluation. The proposed method attained 90.19% classification ACC, 98.8% sensitivity, 85.7% specificity, and a quadratic weighted kappa of 0.888 at slide-based evaluation. Its generalisation capabilities are also studied on two publicly available external datasets.

Indexed as

colorectal cancercomputational pathologyinterpretabilitymultiple-instance learningsemi-supervised learningweakly supervised learning

Identifiers

PMID35626093
PMCPMC9139905
OpenAlexW4280645326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.