Evidence map›Paper›PMID 35626052›Full record

ArticleCancers2022

Acquired αSMA Expression in Pericytes Coincides with Aberrant Vascular Structure and Function in Pancreatic Ductal Adenocarcinoma.

Vikneshwari Natarajan, Sangdeuk Ha, Alexander Delgado, Reed Jacobson, Lina Alhalhooly, Yongki Choi, Jiha Kim

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Mechanisms of Pericyte-Mediated Cancer Metastasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Signaling Role of Pericytes in Vascular Health and Tissue Homeostasis.International journal of molecular sciences · 2024
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Vikneshwari NatarajanDepartment of Biological Science, North Dakota State University, Fargo, ND 58108, USA.
Sangdeuk HaDepartment of Biological Science, North Dakota State University, Fargo, ND 58108, USA.
Alexander DelgadoDepartment of Biological Science, North Dakota State University, Fargo, ND 58108, USA.
Reed JacobsonDepartment of Biological Science, North Dakota State University, Fargo, ND 58108, USA.
Lina AlhalhoolyDepartment of Physics, North Dakota State University, Fargo, ND 58108, USA.
Yongki ChoiMolecular and Cellular Biology Program, North Dakota State University, Fargo, ND 58108, USA.
Jiha KimDepartment of Biological Science, North Dakota State University, Fargo, ND 58108, USA.ORCID 0000-0001-9534-6888
North Dakota State University · US

Funding

Targeting CLEC-2/podoplanin as a therapeutic strategy for pancreatic cancerP20GM109024 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI Sanku Mallik · 2016 to 2026
$20.5M
NIGMS NIH HHS P20 GM109024NIH HHS 1P20GM109024
6 · The paper itself

Abstract

The subpopulations of tumor pericytes undergo pathological phenotype switching, affecting their normal function in upholding structural stability and cross-communication with other cells. In the case of pancreatic ductal adenocarcinoma (PDAC), a significant portion of blood vessels are covered by an α-smooth muscle actin (αSMA)-expressing pericyte, which is normally absent from capillary pericytes. The Desmin

Indexed as

cancer exosomeshypoxiapancreatic ductal adenocarcinoma (PDAC)pericytestumor microenvironment (TME)vascular leakinessα-smooth muscle actin (αSMA)

Identifiers

PMID35626052
PMCPMC9139959
OpenAlexW4280498181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.