Evidence map›Paper›PMID 35626047›Full record

ArticleCancers2022

Non-Robustness of Ang's Risk Classification in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma in Japanese Patients.

Jun Itami, Kenya Kobayashi, Taisuke Mori, Yoshitaka Honma, Yuko Kubo, Naoya Murakami, Go Omura, Kae Okuma, Koji Inaba, Kana Takahashi and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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0 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Jun ItamiDepartment of Radiation Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.ORCID 0000-0003-1579-7406
Kenya KobayashiDepartment of Head and Neck Surgical Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Taisuke MoriDepartment of Pathology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Yoshitaka HonmaDepartment of Head and Neck Medical Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.ORCID 0000-0002-4209-4493
Yuko KuboDepartment of Diagnostic Radiology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Naoya MurakamiDepartment of Radiation Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.ORCID 0000-0003-0660-9987
Go OmuraDepartment of Head and Neck Surgical Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Kae OkumaDepartment of Radiation Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Koji InabaDepartment of Radiation Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Kana TakahashiDepartment of Radiation Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Tairo KashiharaDepartment of Radiation Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Yuri ShimizuDepartment of Radiation Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Ayaka TakahashiDepartment of Radiation Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Yuko NakayamaDepartment of Radiation Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Fumihiko MatsumotoDepartment of Head and Neck Surgical Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.ORCID 0000-0002-0802-8011
Seiichi YoshimotoDepartment of Head and Neck Surgical Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.ORCID 0000-0001-9270-095X
Hiroshi IgakiDepartment of Radiation Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Tokyo National Hospital · JPShinmatsudo Central General Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundValidity of the risk classification by Ang for human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) remains to be studied in the patients treated by modalities other than chemoradiotherapy and in Japanese patients. MATERIALS AND

methodsBetween 2010 and 2018, 122 patients with HPV-related OPSCC in stages III and IV by the TNM classification 7th edition (TNM-7) were treated curatively at a single institution in Japan. The median age was 62.7 years. Over 50% of the patients underwent surgery with or without adjuvant therapy. The influence of multiple factors on survival was analyzed.

resultsThe amount of smoking dichotomized at 10 pack-year, which was used in Ang's risk classification, was not predictive of prognosis, and Ang's risk classification was not significantly influential on prognosis in multivariate analysis. In the patients treated with definitive radiation therapy, Ang's risk classification was not predictive of the prognosis in univariate analysis. The impact of smoking was significant only in the patients undergoing the definitive operation.

conclusionsAng's risk classification was not robust in predicting the prognosis of general Japanese HPV-related OPSCC patients. The amount of smoking might have different prognostic influences depending on the therapeutic method.

Indexed as

human papillomavirusJapanese patientsoropharyngeal cancerp16prognosisrisk classificationsquamous cell cancer

Identifiers

PMID35626047
PMCPMC9139843
OpenAlexW4280498842

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