Evidence map›Paper›PMID 35626041›Full record

ArticleCancers2022

p62 Promotes Survival and Hepatocarcinogenesis in Mice with Liver-Specific NEMO Ablation.

Vangelis Kondylis, Farina Schneider, Fabian Schorn, Nikos Oikonomou, Beate Katharina Straub, Sabine Werner, Philip Rosenstiel, Manolis Pasparakis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Vangelis KondylisInstitute for Genetics, University of Cologne, D-50674 Cologne, Germany.ORCID 0000-0002-6970-8731
Farina SchneiderCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, D-50931 Cologne, Germany.
Fabian SchornCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, D-50931 Cologne, Germany.
Nikos OikonomouInstitute for Genetics, University of Cologne, D-50674 Cologne, Germany.
Beate Katharina StraubInstitute of Pathology, University Hospital Mainz, D-55131 Mainz, Germany.ORCID 0000-0002-4857-1561
Sabine WernerInstitute of Molecular Health Sciences, Department of Biology, ETH Zurich, 8093 Zurich, Switzerland.
Philip RosenstielInstitute of Clinical Molecular Biology, Christian Albrecht University of Kiel, Schleswig-Holstein University Hospital, D-24105 Kiel, Germany.
Manolis PasparakisInstitute for Genetics, University of Cologne, D-50674 Cologne, Germany.ORCID 0000-0002-9870-0966
University of Cologne · DEChristian-Albrechts-Universität zu Kiel · DEETH Zurich · CHJohannes Gutenberg University Mainz · DE

Funding

Deutsche Forschungsgemeinschaft Proposal no KO 5827/2-1; project no. 415274764)European Union FP7-PEOPLE-2010-IEF; Proposal No: 275767
6 · The paper itself

Abstract

SQSTM1/p62 is a multitasking protein that functions as an autophagy receptor, but also as a signaling hub regulating diverse cellular pathways. p62 accumulation in mice with autophagy-deficient hepatocytes mediates liver damage and hepatocarcinogenesis through Nrf2 overactivation, yet the role of the p62-Keap1-Nrf2 axis in cell death and hepatocarcinogenesis in the absence of underlying autophagy defects is less clear. Here, we addressed the role of p62 and Nrf2 activation in a chronic liver disease model, namely mice with liver parenchymal cell-specific knockout of NEMO (NEMO

Indexed as

autophagychronic liver diseasegenetic mouse modelshepatocarcinogenesisIκB kinase (IKK) complexKeap1-Nrf2 activationliver injury

Identifiers

PMID35626041
PMCPMC9139637
OpenAlexW4280634174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.