Evidence map›Paper›PMID 35626031›Full record

ArticleCancers2022

Clinical Impact of Pathogenic Variants in DNA Damage Repair Genes beyond

Whitney Espinel, Marjan Champine, Heather Hampel, Joanne Jeter, Kevin Sweet, Robert Pilarski, Rachel Pearlman, Kate Shane, Pamela Brock, Judith A Westman and 18 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 4 institutions in 1 country.

Whitney EspinelHuntsman Cancer Institute, Salt Lake City, UT 84112, USA.ORCID 0000-0002-7159-9239
Marjan ChampineHuntsman Cancer Institute, Salt Lake City, UT 84112, USA.
Heather HampelOhio State University Medical Center, Columbus, OH 43210, USA.
Joanne JeterOhio State University Medical Center, Columbus, OH 43210, USA.
Kevin SweetOhio State University Medical Center, Columbus, OH 43210, USA.ORCID 0000-0002-9131-347X
Robert PilarskiOhio State University Medical Center, Columbus, OH 43210, USA.ORCID 0000-0001-7894-1482
Rachel PearlmanOhio State University Medical Center, Columbus, OH 43210, USA.
Kate ShaneOhio State University Medical Center, Columbus, OH 43210, USA.
Pamela BrockOhio State University Medical Center, Columbus, OH 43210, USA.
Judith A WestmanOhio State University Medical Center, Columbus, OH 43210, USA.
Lindsay KipnisDana Farber Cancer Institute, Boston, MA 02215, USA.
Jilliane SoteloDana Farber Cancer Institute, Boston, MA 02215, USA.
Anu ChittendenDana Farber Cancer Institute, Boston, MA 02215, USA.
Samantha CulverDana Farber Cancer Institute, Boston, MA 02215, USA.
Jill E StopferDana Farber Cancer Institute, Boston, MA 02215, USA.
Katherine A SchneiderDana Farber Cancer Institute, Boston, MA 02215, USA.
Rosalba SaccaDana Farber Cancer Institute, Boston, MA 02215, USA.
Diane R KoellerDana Farber Cancer Institute, Boston, MA 02215, USA.
Shraddha GaonkarDana Farber Cancer Institute, Boston, MA 02215, USA.
Erica VaccariDana Farber Cancer Institute, Boston, MA 02215, USA.
Sarah KaneDana Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0003-1936-7067
Scott T MichalskiInvitae, San Francisco, CA 94103, USA.
Shan YangInvitae, San Francisco, CA 94103, USA.
Sarah M NielsenInvitae, San Francisco, CA 94103, USA.
Sara L BristowInvitae, San Francisco, CA 94103, USA.ORCID 0000-0002-1173-4718
Stephen E LincolnInvitae, San Francisco, CA 94103, USA.
Robert L NussbaumInvitae, San Francisco, CA 94103, USA.
Edward D EsplinInvitae, San Francisco, CA 94103, USA.ORCID 0000-0001-9205-3756
Dana-Farber Cancer Institute · USThe Ohio State University Wexner Medical Center · USInvitae (United States) · USHuntsman Cancer Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Consensus guidelines for hereditary breast and ovarian cancer include management recommendations for pathogenic/likely pathogenic (P/LP) variants in

Indexed as

breast cancerclinical managementclinical utilityDNA damage repairgenetic testingmoderate-risk genesovarian cancer

Identifiers

PMID35626031
PMCPMC9139211
OpenAlexW4280630460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.