Evidence map›Paper›PMID 35625960›Full record

ArticleCancers2022

Molecular Subtypes Based on Genomic and Transcriptomic Features Correlate with the Responsiveness to Immune Checkpoint Inhibitors in Metastatic Clear Cell Renal Cell Carcinoma.

ByulA Jee, Eunjeong Seo, Kyunghee Park, Yi Rang Kim, Sun-Ju Byeon, Sang Min Lee, Jae Hoon Chung, Wan Song, Hyun Hwan Sung, Hwang Gyun Jeon and 7 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

ByulA JeeDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06531, Korea.
Eunjeong SeoDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06531, Korea.
Kyunghee ParkSamsung Genome Institute, Samsung Medical Center, Seoul 06531, Korea.ORCID 0000-0003-0511-4958
Yi Rang KimOncocross Ltd., Seoul 04168, Korea.ORCID 0000-0001-9864-5453
Sun-Ju ByeonDepartment of Pathology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong 18450, Korea.ORCID 0000-0002-9599-4970
Sang Min LeeDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06531, Korea.
Jae Hoon ChungDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06531, Korea.
Wan SongDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06531, Korea.
Hyun Hwan SungDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06531, Korea.
Hwang Gyun JeonDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06531, Korea.
Byong Chang JeongDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06531, Korea.
Seong Il SeoDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06531, Korea.
Seong Soo JeonDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06531, Korea.
Hyun Moo LeeDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06531, Korea.
Se Hoon ParkDivision of Hematology-Oncology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06531, Korea.
Woong-Yang ParkSamsung Genome Institute, Samsung Medical Center, Seoul 06531, Korea.ORCID 0000-0003-4234-0380
Minyong KangDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06531, Korea.
Samsung Medical Center · KRHallym University Dongtan Sacred Heart Hospital · KRSamsung (South Korea) · KR

Funding

Hallym University 2018-30Ministry of Health and Welfare HA17C0039National Research Foundation of Korea 2018R1A6A3A11046060National Research Foundation of Korea 2020R1A2C2007662National Research Foundation of Korea 2020R1C1C1005054National Research Foundation of Korea 2021R1I1A1A01040437
6 · The paper itself

Abstract

Clear cell renal cell carcinoma (ccRCC) has been reported to be highly immune to and infiltrated by T cells and has angiogenesis features, but the effect of given features on clinical outcomes followed by immune checkpoint inhibitors (ICIs) in ccRCC has not been fully characterized. Currently, loss of function mutation in

Indexed as

immune checkpoint inhibitormolecular featuresrenal cell carcinomaresponsiveness

Identifiers

PMID35625960
PMCPMC9139776
OpenAlexW4280612881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.