ArticleBiomedicines2022
Multi-Level Analysis of Adipose Tissue Reveals the Relevance of Perivascular Subpopulations and an Increased Endothelial Permeability in Early-Stage Lipedema.
Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Impact of hormones on lipedema development: a systematic literature review.Archives of gynecology and obstetrics · 2026Pooled it
- Lipedema and obesity: biological interactions, diagnostic challenges, and principles of interdisciplinary management - a narrative review.Adipocyte · 2026Review
- Article
- Reduced Serum Endostatin in Premenopausal Women with Lipedema Suggests Altered Vascular Homeostasis.Diseases (Basel, Switzerland) · 2026Article
- From Endometriosis to Lipedema: Toward a Neuroimmune Framework for Pain Amplification in Hormone-Sensitive Disorders.Biomedicines · 2026Review
- Lipedema in Women and Its Interrelationship with Endometriosis and Other Gynecologic Diseases: A Scoping Review.Biomedicines · 2026Review
- Lipedema as a disorder of adipose tissue heterogeneity: insights from single-cell and spatial transcriptomics.Frontiers in cell and developmental biology · 2026Review
- Lipedema as a hormone-sensitive stromal disorder: a four-pathway translational framework.Frontiers in cell and developmental biology · 2026Article
- New Frontiers in modeling the lipedema microenvironmentFrontiers in cell and developmental biology · 2026Review
- Vascular changes and their implications in lipedema.Frontiers in cell and developmental biology · 2026Review
- An Advanced Pneumatic Compression Therapy System Improves Leg Volume and Fluid, Adipose Tissue Thickness, Symptoms, and Quality of Life and Reduces Risk of Lymphedema in Women with Lipedema.Life (Basel, Switzerland) · 2025Article
- Endothelial cell alterations in capillaries of adipose tissue from patients affected by lipedema.Obesity (Silver Spring, Md.) · 2025Article
- Lipedema: A Disease Triggered by M2 Polarized Macrophages?Biomedicines · 2025Review
- Article
- Identification of Specific microRNAs in Adipose Tissue Affected by Lipedema.Current issues in molecular biology · 2024Article
- Is the endotoxin-complement cascade the major driver in lipedema?Trends in endocrinology and metabolism: TEM · 2024Review
- Preliminary Single-Cell RNA-Sequencing Analysis Uncovers Adipocyte Heterogeneity in Lipedema.Cells · 2024Article
- National survey of patient symptoms and therapies among 707 women with a lipedema phenotype in the United States.Vascular medicine (London, England) · 2024Article
- Enhanced Angiogenesis in HUVECs Preconditioned with Media from Adipocytes Differentiated from Lipedema Adipose Stem Cells In Vitro.International journal of molecular sciences · 2023Article
- Lipedema Research-Quo Vadis?Journal of personalized medicine · 2022Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Lipedema is a chronic, progressive disease of adipose tissue with unknown etiology. Based on the relevance of the stromal vascular fraction (SVF) cell population in lipedema, we performed a thorough characterization of subcutaneous adipose tissue, SVF isolated thereof and the sorted populations of endothelial cells (EC), pericytes and cultured adipose-derived stromal/stem cells (ASC) of early-stage lipedema patients. We employed histological and gene expression analysis and investigated the endothelial barrier by immunofluorescence and analysis of endothelial permeability in vitro. Although there were no significant differences in histological stainings, we found altered gene expression of factors relevant for local estrogen metabolism (aromatase), preadipocyte commitment (ZNF423) and immune cell infiltration (CD11c) in lipedema on the tissue level, as well as in distinct cellular subpopulations. Machine learning analysis of immunofluorescence images of CD31 and ZO-1 revealed a morphological difference in the cellular junctions of EC cultures derived from healthy and lipedema individuals. Furthermore, the secretome of lipedema-derived SVF cells was sufficient to significantly increase leakiness of healthy human primary EC, which was also reflected by decreased mRNA expression of VE-cadherin. Here, we showed for the first time that the secretome of SVF cells creates an environment that triggers endothelial barrier dysfunction in early-stage lipedema. Moreover, since alterations in gene expression were detected on the cellular and/or tissue level, the choice of sample material is of high importance in elucidating this complex disease.
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Registered trials
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