Evidence map›Paper›PMID 35625889›Full record

ArticleBiomedicines2022

Low Density Lipoprotein Exposure of Plasmacytoid Dendritic Cells Blunts Toll-like Receptor 7/9 Signaling via NUR77.

Anette Christ, Pieter G Goossens, Erwin Wijnands, Han Jin, Bart Legein, Tammy Oth, Aaron Isaacs, Monika Stoll, Joris Vanderlocht, Esther Lutgens and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Innate Immune Cells in Melanoma: Implications for Immunotherapy.International journal of molecular sciences · 2024
    Review
  3. Zinc-Organometallic Framework Vaccine Controlled-Release ZnAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Anette ChristInstitute of Innate Immunity, University of Bonn, 53127 Bonn, Germany.ORCID 0000-0003-0829-6179
Pieter G GoossensDepartment of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229 HX Maastricht, The Netherlands.ORCID 0000-0002-7269-6372
Erwin WijnandsDepartment of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229 HX Maastricht, The Netherlands.
Han JinDepartment of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229 HX Maastricht, The Netherlands.ORCID 0000-0002-0955-6289
Bart LegeinDepartment of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229 HX Maastricht, The Netherlands.
Tammy OthCentral Diagnostic Laboratory, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands.
Aaron IsaacsDepartment of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229 HX Maastricht, The Netherlands.
Monika StollDepartment of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229 HX Maastricht, The Netherlands.ORCID 0000-0002-2711-4281
Joris VanderlochtCentral Diagnostic Laboratory, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands.
Esther LutgensAmsterdam Medical Center, 1105 AZ Amsterdam, The Netherlands.
Mat J A P DaemenAmsterdam Medical Center, 1105 AZ Amsterdam, The Netherlands.
Martin ZenkeDepartment of Hematology, Oncology and Stem Cell Transplantation, RWTH Aachen University Medical School, 52074 Aachen, Germany.ORCID 0000-0002-1107-3251
Erik A L BiessenDepartment of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229 HX Maastricht, The Netherlands.
Maastricht University · NLAmsterdam University Medical Centers · NLRWTH Aachen University · DEUniversity of Bonn · DE

Funding

Deutsche Forschungsgemeinschaft GRK1508Interreg EMR Healthy AgeingNetherlands Organisation for Health Research and Development DNAMoving
6 · The paper itself

Abstract

backgroundPathogens or trauma-derived danger signals induced maturation and activation of plasmacytoid dendritic cells (pDCs) is a pivotal step in pDC-dependent host defense. Exposure of pDC to cardiometabolic disease-associated lipids and proteins may well influence critical signaling pathways, thereby compromising immune responses against endogenous, bacterial and viral pathogens. In this study, we have addressed if hyperlipidemia impacts human pDC activation, cytokine response and capacity to prime CD4 METHODS AND

resultsWe show that exposure to pro-atherogenic oxidized low-density lipoproteins (oxLDL) led to pDC lipid accumulation, which in turn ablated a Toll-like receptor (TLR) 7 and 9 dependent up-regulation of pDC maturation markers CD40, CD83, CD86 and HLA-DR. Moreover, oxLDL dampened TLR9 activation induced the production of pro-inflammatory cytokines in a NUR77/IRF7 dependent manner and impaired the capacity of pDCs to prime and polarize CD4

conclusionOur findings reveal profound effects of dyslipidemia on pDC responses to pathogen-derived signals.

Indexed as

cholesteroldendritic cellsinterferonnuclear receptortoll like receptorsviral response

Identifiers

PMID35625889
PMCPMC9139034
OpenAlexW4280589858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.