Evidence map›Paper›PMID 35625873›Full record

ArticleBiomedicines2022

Naphthoquinone as a New Chemical Scaffold for Leishmanicidal Inhibitors of

Victor Sebastián-Pérez, Paula Martínez de Iturrate, Montserrat Nácher-Vázquez, Luis Nóvoa, Concepción Pérez, Nuria E Campillo, Carmen Gil, Luis Rivas

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Victor Sebastián-PérezCentro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), 28040 Madrid, Spain.
Paula Martínez de IturrateCentro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), 28040 Madrid, Spain.
Montserrat Nácher-VázquezCentro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), 28040 Madrid, Spain.ORCID 0000-0001-8355-8373
Luis NóvoaCentro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), 28040 Madrid, Spain.
Concepción PérezInstituto de Química Médica (IQM-CSIC), 28006 Madrid, Spain.ORCID 0000-0001-7183-4035
Nuria E CampilloCentro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), 28040 Madrid, Spain.
Carmen GilCentro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), 28040 Madrid, Spain.ORCID 0000-0002-3882-6081
Luis RivasCentro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), 28040 Madrid, Spain.ORCID 0000-0002-2958-3233
Centro de Investigaciones Biológicas Margarita Salas · ESInstituto de Química Médica · ES

Funding

European Social Fund Youth Employment InitiativeInstituto de Salud Carlos III FEDER funds (RD16/0027/0010)Ministry of Economy, Industry and Competitiveness FEDER funds (SAF2015-65740-R)Ministry of Economy, Industry and Competitiveness FPU15/1465
6 · The paper itself

Abstract

More than 1 billion people live in areas endemic for leishmaniasis, which is a relevant threat for public health worldwide. Due to the inadequate treatments, there is an urgent need to develop novel alternative drugs and to validate new targets to fight this disease. One appealing approach is the selective inhibition of protein kinases (PKs), enzymes involved in a wide range of processes along the life cycle of

Indexed as

GSK-3hit optimizationleishmaniasisleishmanicidal drugsligand-based drug discovery

Identifiers

PMID35625873
PMCPMC9139002
OpenAlexW4280647287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.