Evidence map›Paper›PMID 35625842›Full record

ArticleBiomedicines2022

Urinary KIM-1 Correlates with the Subclinical Sequelae of Tubular Damage Persisting after the Apparent Functional Recovery from Intrinsic Acute Kidney Injury.

Cristina Cuesta, Isabel Fuentes-Calvo, Sandra M Sancho-Martinez, Floris A Valentijn, Annette Düwel, Omar A Hidalgo-Thomas, Consuelo Agüeros-Blanco, Adalberto Benito-Hernández, María A Ramos-Barron, Carlos Gómez-Alamillo and 5 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Cristina CuestaInstitute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.ORCID 0000-0002-5430-4611
Isabel Fuentes-CalvoInstitute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.
Sandra M Sancho-MartinezInstitute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.
Floris A ValentijnDepartment of Pathology, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands.ORCID 0000-0003-3676-6596
Annette DüwelInstitute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.
Omar A Hidalgo-ThomasInstitute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.
Consuelo Agüeros-BlancoServicio de Nefrología, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), 39011 Santander, Spain.
Adalberto Benito-HernándezServicio de Nefrología, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), 39011 Santander, Spain.
María A Ramos-BarronServicio de Nefrología, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), 39011 Santander, Spain.ORCID 0000-0003-1537-7559
Carlos Gómez-AlamilloServicio de Nefrología, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), 39011 Santander, Spain.
Manuel AriasServicio de Nefrología, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), 39011 Santander, Spain.
Tri Q NguyenDepartment of Pathology, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands.ORCID 0000-0001-6475-0706
Roel GoldschmedingDepartment of Pathology, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands.
Carlos Martínez-SalgadoInstitute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.ORCID 0000-0003-4641-6717
Francisco J López-HernándezInstitute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.ORCID 0000-0001-7778-7495
Universidad de Salamanca · ESInstituto de Investigación Marqués de Valdecilla · ESUniversity Medical Center Utrecht · NL

Funding

Instituto de Salud Carlos III PI10/00624, PI15/01055, PI18/00996, PI21/01226, PI21/00548 and RETICS RD016/0009/0025
6 · The paper itself

Abstract

Acute kidney injury (AKI) poses an increased risk factor for new AKI episodes, progression to chronic kidney disease, and death. A worsened evolution has been linked to an incomplete renal repair beyond the apparent functional recovery based on plasma creatinine (pCr) normalization. However, structural sequelae pass largely unnoticed due to the absence of specific diagnostic tools. The urinary kidney injury molecule 1 (KIM-1) participates in renal tissue damage and repair and is proposed as a biomarker of early and subclinical AKI. Thus, we study in this paper the evolution of KIM-1 urinary excretion alongside renal tissue sequelae after an intrinsic AKI episode induced by cisplatin in Wistar rats. Creatinine clearance, pCr, proteinuria and the fractional excretion of Na

Indexed as

acute kidney injurybiomarkerKIM-1subclinical sequelae

Identifiers

PMID35625842
PMCPMC9139078
OpenAlexW4280585233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.