Evidence map›Paper›PMID 35625834›Full record

ArticleBiomedicines2022

Strategy to Enhance Anticancer Activity and Induced Immunogenic Cell Death of Antimicrobial Peptides by Using Non-Nature Amino Acid Substitutions.

Yu-Huan Cheah, Chun-Yu Liu, Bak-Sau Yip, Chih-Lung Wu, Kuang-Li Peng, Jya-Wei Cheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yu-Huan CheahDepartment of Medical Science, Institute of Biotechnology, National Tsing Hua University, Hsinchu 300, Taiwan.
Chun-Yu LiuDepartment of Medical Science, Institute of Biotechnology, National Tsing Hua University, Hsinchu 300, Taiwan.
Bak-Sau YipDepartment of Medical Science, Institute of Biotechnology, National Tsing Hua University, Hsinchu 300, Taiwan.
Chih-Lung WuDepartment of Medical Science, Institute of Biotechnology, National Tsing Hua University, Hsinchu 300, Taiwan.
Kuang-Li PengDepartment of Medical Science, Institute of Biotechnology, National Tsing Hua University, Hsinchu 300, Taiwan.
Jya-Wei ChengDepartment of Medical Science, Institute of Biotechnology, National Tsing Hua University, Hsinchu 300, Taiwan.ORCID 0000-0003-3331-691X
National Tsing Hua University · TW

Funding

Ministry of Science and Technology, Taiwan 110-2113-M-007 -021
6 · The paper itself

Abstract

There is an urgent and imminent need to develop new agents to fight against cancer. In addition to the antimicrobial and anti-inflammatory activities, many antimicrobial peptides can bind to and lyse cancer cells. P-113, a 12-amino acid clinically active histatin-rich peptide, was found to possess anti-

Indexed as

antimicrobial peptidesbulky non-nature amino acidcancerDAMPsmembrane integrityoncolytic peptides

Identifiers

PMID35625834
PMCPMC9138567
OpenAlexW4229451511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.