Evidence map›Paper›PMID 35625802›Full record

ReviewBiomedicines2022

(Dis)similarities between the Decidual and Tumor Microenvironment.

Jelena Krstic, Alexander Deutsch, Julia Fuchs, Martin Gauster, Tina Gorsek Sparovec, Ursula Hiden, Julian Christopher Krappinger, Gerit Moser, Katrin Pansy, Marta Szmyra and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Immunologic aspects of preeclampsia.AJOG global reports · 2024
    Review
  9. Article
  10. Article
  11. Placenta: an old organ with new functions.Frontiers in immunology · 2024
    Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Jelena KrsticDivision of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010 Graz, Austria.ORCID 0000-0002-3423-533X
Alexander DeutschDivision of Hematology, Medical University of Graz, Stiftingtalstrasse 24, 8010 Graz, Austria.ORCID 0000-0003-0914-2809
Julia FuchsDivision of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010 Graz, Austria.ORCID 0000-0003-4576-615X
Martin GausterDivision of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010 Graz, Austria.ORCID 0000-0003-0386-6857
Tina Gorsek SparovecDepartment of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, 8036 Graz, Austria.ORCID 0000-0001-8911-0123
Ursula HidenDepartment of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, 8036 Graz, Austria.ORCID 0000-0001-8009-020X
Julian Christopher KrappingerDivision of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010 Graz, Austria.ORCID 0000-0002-8855-087X
Gerit MoserDivision of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010 Graz, Austria.ORCID 0000-0002-9917-0629
Katrin PansyDivision of Hematology, Medical University of Graz, Stiftingtalstrasse 24, 8010 Graz, Austria.ORCID 0000-0001-6972-4937
Marta SzmyraDivision of Hematology, Medical University of Graz, Stiftingtalstrasse 24, 8010 Graz, Austria.ORCID 0000-0003-0854-5243
Daniela GoldDepartment of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, 8036 Graz, Austria.ORCID 0000-0002-7196-454X
Julia FeichtingerDivision of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010 Graz, Austria.ORCID 0000-0002-3667-5857
Berthold HuppertzDivision of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010 Graz, Austria.ORCID 0000-0003-4814-2158
Medical University of Graz · AT

Funding

Austrian Science Fund FWF DOC 31Austrian Science Fund FWF T 923
6 · The paper itself

Abstract

Placenta-specific trophoblast and tumor cells exhibit many common characteristics. Trophoblast cells invade maternal tissues while being tolerated by the maternal immune system. Similarly, tumor cells can invade surrounding tissues and escape the immune system. Importantly, both trophoblast and tumor cells are supported by an abetting microenvironment, which influences invasion, angiogenesis, and immune tolerance/evasion, among others. However, in contrast to tumor cells, the metabolic, proliferative, migrative, and invasive states of trophoblast cells are under tight regulatory control. In this review, we provide an overview of similarities and dissimilarities in regulatory processes that drive trophoblast and tumor cell fate, particularly focusing on the role of the abetting microenvironments.

Indexed as

decidual microenvironmentimmune cellsinvasionplacentaproliferationtrophoblasttumor celltumor microenvironment

Identifiers

PMID35625802
PMCPMC9138511
OpenAlexW4225392277

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.